Maternal Pre-pregnancy Body Mass Index and Autism Spectrum Disorder among Offspring: A Population-Based Case-Control Study.
Maternal Pre-pregnancy Body Mass Index and Autism Spectrum Disorder among Offspring: A Population-Based Case-Control Study.
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DOI：
10.1111/ppe.12306
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发表时间：
2016-09
影响因子：
2.8
通讯作者：
Jick SS
中科院分区：
文献类型：
--
作者：
Getz KD;Anderka MT;Werler MM;Jick SS
以前的研究将怀孕期间母亲体重增加和孕前肥胖归因于自闭症谱系障碍（ASD）的风险较高。母亲体重不足以前没有探讨ASD的风险。我们评估了1993年至2008年全科医学研究数据库中出生的单胎孕妇孕前体重指数（BMI）与ASD发生率之间的关系。病例受试者是从出生到2010年被诊断为ASD的儿童。最多4名对照组受试者与每个病例受试者在出生年份、性别和一般实践方面相匹配。限制性三次样条用于评估母体BMI和ASD之间的关联的非线性。所有研究受试者根据母亲孕前BMI使用WHO分类标准分为体重不足、正常体重、超重或肥胖。条件Logistic回归用于计算分类BMI（参考=正常体重）和ASD发生之间关联的粗和多变量调整比值比。母亲BMI和ASD发生之间的关联是非线性和J形的（p=0.003）。母亲体重不足和肥胖的校正OR分别为1.43 [95% CI：1.01，2.04]和1.54 [95% CI：1.26，1.89]。结果表明，母亲BMI的极端可能与后代ASD风险的适度增加有关。
Previous studies have attributed high maternal weight gain during pregnancy and pre-pregnancy obesity to a higher risk for autism spectrum disorders (ASD). Maternal underweight was not previously explored with respect to ASD risk. We evaluated the association between maternal pre-pregnancy body mass index (BMI) and ASD occurrence among singletons born into the General Practice Research Database from 1993 through 2008. Case subjects were children with a diagnosis of ASD from birth through 2010. Up to four control subjects were matched to each case subject on birth year, sex, and general practice. Restricted cubic splines were used to assess the non-linearity of the association between maternal BMI and ASD. All study subjects were classified as underweight, normal weight, overweight or obese based on maternal pre-pregnancy BMI using the WHO Classification Standard. Conditional logistic regression was used to calculate crude and multivariable adjusted odds ratios for the association between categorical BMI (reference=normal weight) and the occurrence of ASD The association between maternal BMI and ASD occurrence was non-linear and J-shaped (p=0.003). The adjusted ORs for maternal underweight and obesity were 1.43 [95% CI: 1.01, 2.04] and 1.54 [95% CI: 1.26, 1.89], respectively. Results suggest that extremes in maternal BMI may be associated with modest increases in the risk for ASD among offspring.
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影响因子：
4.5
作者：
Fombonne E;Heavey L;Smeeth L;Rodrigues LC;Cook C;Smith PG;Meng L;Hall AJ
通讯作者：
Hall AJ
影响因子：
2
作者：
DURRLEMAN, S;SIMON, R
通讯作者：
SIMON, R
影响因子：
7.2
作者：
Jacobsson, B;Ladfors, L;Milsom, I
通讯作者：
Milsom, I
影响因子：
3.4
作者：
Curry, A. E.;Vogel, I.;Thorsen, P.
通讯作者：
Thorsen, P.
DOI：
10.1111/j.1469-7610.2006.01714.x
发表时间：
2007-03-01
影响因子：
7.6
作者：
Talge, Nicole M.;Neal, Charles;Glover, Vivette
通讯作者：
Glover, Vivette