Influence of suspended sediment on the bioavailability of benzophenone-3: Focus on accumulation and multi-biological effects in Daphnia magna.
Influence of suspended sediment on the bioavailability of benzophenone-3: Focus on accumulation and multi-biological effects in Daphnia magna.
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悬浮沉积物对二苯甲酮-3 生物利用度的影响：重点关注大型溞中的积累和多生物效应。
DOI：
10.1016/j.chemosphere.2021.129974
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发表时间：
2021-02
期刊：
影响因子：
8.8
通讯作者：
Jianchao Liu
中科院分区：
文献类型：
--
作者：
Haohan Yang;Guanghua Lu;Zhenhua Yan;Jianchao Liu
紫外线过滤剂二苯甲酮-3（BP 3）的疏水性使其易于与悬浮泥沙（SPS）结合，从而改变其对非目标水生生物的毒性效应。本研究以大型枝角类动物Daphnia magna（D. magna）为模式生物，研究了SPS的来源和组成对BP 3的积累和多重毒理效应（从分子水平到个体水平）的影响。在SPS的三种组分中，无定形有机碳（AOC）和矿物质促进了BP 3的体内负荷，而黑碳（BC）抑制了BP 3的生物积累。AOC和BC的存在增强了BP 3对大型蚤游泳和摄食行为的抑制作用。与BP 3单独暴露相比，含有AOC、BC和矿物质的SPS暴露可引起更高的氧化应激和神经毒性，表现为对超氧化物歧化酶（SOD）、过氧化氢酶（CAT）和谷胱甘肽-S-转移酶（GST）活性的进一步诱导，对乙酰胆碱酯酶（AchE）活性的抑制。此外，BP 3诱导内分泌系统（蜕皮激素受体，细胞色素P450 CYP 314）和代谢系统（毒性核受体HR 96，P-糖蛋白）的mRNA表达水平，并且含有AOC、BC和矿物质的SPS的存在表现出增强效应。结合所有终点，观察到生物累积水平与个体行为和分子生物标志物的响应之间存在明显的相关性。研究结果表明，在水环境中，SPS组分对有机紫外线过滤剂的生物累积和毒理效应的影响应予以考虑。
The UV-filter benzophenone-3 (BP3) tends to associate with suspended sediment (SPS) due to hydrophobicity, which could alter its toxicological effects on non-target aquatic organisms. In this study, the freshwater cladoceranDaphnia magna(D. magna) was selected as a model organism to investigate the impacts of the source and composition of SPS on the accumulation and multiple toxicological effects (from the molecular level to individual level) of BP3. Among the three components of SPS, amorphous organic carbon (AOC) and minerals promoted the body burden of BP3, while black carbon (BC) inhibited the bioaccumulation. The inhibition effects of BP3 on swimming and feeding behaviors ofD. magnawere also enhanced due to the presence of AOC and BC. Compared with BP3 exposure alone, higher oxidative stress and neurotoxicity were observed in the presence of SPS containing AOC, BC and minerals, corresponding to that superoxide dismutase, catalase and glutathione-S-transferase activities were further induced, and acetylcholinesterase activity was inhibited. Furthermore, BP3 induced mRNA expression levels of the endocrine system (ecdysone receptor, cytochrome P450CYP314) and metabolic system (toxicant nuclear receptorHR96, P-glycoprotein), and the presence of SPS containing AOC, BC and minerals exhibited an enhanced effect. Combined with all endpoints, evident relationship was observed between the bioaccumulation level and the response of individual behavior and molecular biomarkers. The results demonstrated that the effects of SPS compositions on bioaccumulation and toxicological effects of organic UV-filters should be considered in aquatic environments.
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DOI：
10.2174/187569209788654005
发表时间：
2009-06-01
影响因子：
--
作者：
Hernandez JP;Mota LC;Baldwin WS
通讯作者：
Baldwin WS
影响因子：
--
作者：
Gaiser, Birgit K.;Biswas, Anamika;Fernandes, Teresa F.
通讯作者：
Fernandes, Teresa F.
影响因子：
11.4
作者：
Mao, Feijian;You, Luhua;Gin, Karina Yew-Hoong
通讯作者：
Gin, Karina Yew-Hoong
影响因子：
5.6
作者：
Saddam Charaabi;Lucien Tchara;Christelle Marminon;Z. Bouaziz;Gérard Holtzinger;A. Pensé-Lhéritier;M. Le Borgne;S. Issa
通讯作者：
Saddam Charaabi;Lucien Tchara;Christelle Marminon;Z. Bouaziz;Gérard Holtzinger;A. Pensé-Lhéritier;M. Le Borgne;S. Issa
影响因子：
2.9
作者：
M. H. R. Khan;Jianguo Liu;Shengfa Liu;A. Seddique;Li Cao;Ananna Rahman
通讯作者：
M. H. R. Khan;Jianguo Liu;Shengfa Liu;A. Seddique;Li Cao;Ananna Rahman