Tolerance to the rate-increasing and not rate-decreasing effects of pregnanolone in rats.
Tolerance to the rate-increasing and not rate-decreasing effects of pregnanolone in rats.
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大鼠对孕烯醇酮增加速率而不是降低速率作用的耐受性。
DOI：
10.1097/fbp.0b013e32833fa79d
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发表时间：
2010
影响因子：
1.6
通讯作者：
Gerak,LisaR
中科院分区：
文献类型：
--
作者：
Eppolito,AmyK;Gerak,LisaR
Chronic treatment with benzodiazepines, which positively modulate γ-aminobutyric acid A (GABA A) receptors, can lead to the development of tolerance. Similar effects might also occur during chronic treatment with positive modulators acting at other sites on GABA A receptors (eg neuroactive steroids). In this study, tolerance and cross tolerance were examined in seven rats treated daily with the neuroactive steroid pregnanolone (25.6 mg/kg/day) and responding under a fixed ratio 10 schedule of food presentation. Dose–effect curves were determined for positive GABA A modulators (pregnanolone, flunitrazepam, midazolam, and pentobarbital), and other drugs (ketamine and morphine) before, during, and after chronic treatment. Initially, daily pregnanolone administration increased responding; although tolerance developed to the rate-increasing effects after 14 weeks, tolerance did not develop to the rate-decreasing effects. The potencies of pregnanolone, midazolam, and morphine to decrease responding did not change during treatment, whereas flunitrazepam was more potent and pentobarbital and ketamine were less potent during treatment as compared to before treatment. Pregnanolone and midazolam were more potent after treatment than before treatment. The development of tolerance to the rate-increasing effects of pregnanolone indicates that neuroadaptations occur during chronic treatment; the fact that tolerance develops to only some effects suggests that the behavioral consequences of these neuroadaptations are limited.
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从豚鼠血小板中纯化肝素中和蛋白并与人血小板因子 4 进行比较。
影响因子：
3.9
作者：
E. Maguire;R. Wallis
通讯作者：
R. Wallis
凝血酶诱导的血小板聚集是由血小板质膜结合的凝集素介导的。
影响因子：
56.9
作者：
T. Gartner;D. Williams;F. Minion;D. Phillips
通讯作者：
D. Phillips
根据氨基酸序列预测血小板因子 4 和 β-血栓球蛋白的二级结构。
影响因子：
7.5
作者：
J. Lawler
通讯作者：
J. Lawler
血小板因子 4。结晶和 X 射线衍射研究。
DOI：
--
发表时间：
1978
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
K. Kurachi
通讯作者：
K. Kurachi
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影响因子：
5.6
作者：
StCharles,R;Ciaglowski,RE;Walz,D;Edwards,BF
通讯作者：
Edwards,BF