Biomineralization and matrix vesicles in biology and pathology.
Biomineralization and matrix vesicles in biology and pathology.
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DOI：
10.1007/s00281-010-0230-z
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发表时间：
2011-09
影响因子：
9
通讯作者：
Golub, Ellis E.
中科院分区：
文献类型：
--
作者：
Golub, Ellis E.
在正常的健康个体中，矿物质形成仅限于形成骨骼和牙列的专门组织。在这些组织中，矿物质的形成在生长和发育以及正常的成年生活中都受到严格控制。骨骼和牙齿组织中钙化的机制已经研究了相当长的一段时间。几乎所有这些正常矿化机制的一个共同特征是基质囊泡（小的（20-200 nm）膜颗粒）的精心制作，其从矿化细胞的质膜出芽并释放到预矿化的有机基质中。在这种有机基质上形成的第一个晶体可以在基质囊泡内和周围看到。病理性异位矿化见于许多人类遗传和获得性疾病，包括导致骨关节炎的关节软骨钙化和导致动脉粥样硬化恶化和血管阻塞的心血管矿化。令人惊讶的是，越来越多的证据支持软组织钙化的机制与正常骨骼发育中所见的机制相似的论点。特别是，在一些异位钙化中观察到基质囊泡样膜。这篇综述的目的是描述基质囊泡在正常矿物质形成中的作用，并回顾它们参与病理性钙化的证据。
In normal healthy individuals, mineral formation is restricted to specialized tissues which form the skeleton and the dentition. Within these tissues, mineral formation is tightly controlled both in growth and development and in normal adult life. The mechanism of calcification in skeletal and dental tissues has been under investigation for a considerable period. One feature common to almost all of these normal mineralization mechanisms is the elaboration of matrix vesicles, small (20–200 nm) membrane particles, which bud off from the plasma membrane of mineralizing cells and are released into the pre-mineralized organic matrix. The first crystals which form on this organic matrix are seen in and around matrix vesicles. Pathologic ectopic mineralization is seen in a number of human genetic and acquired diseases, including calcification of joint cartilage resulting in osteoarthritis and mineralization of the cardiovasculature resulting in exacerbation of atherosclerosis and blockage of blood vessels. Surprisingly, increasing evidence supports the contention that the mechanisms of soft tissue calcification are similar to those seen in normal skeletal development. In particular, matrix vesicle-like membranes are observed in a number of ectopic calcifications. The purpose of this review is to describe how matrix vesicles function in normal mineral formation and review the evidence for their participation in pathologic calcification.
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影响因子：
6
作者：
Anderson, HC;Harmey, D;Millán, JL
通讯作者：
Millán, JL
DOI：
10.1083/jcb.35.1.81
发表时间：
1967-10
期刊：
The Journal of cell biology
影响因子：
--
作者：
Anderson HC
通讯作者：
Anderson HC
DOI：
10.1016/0169-6009(92)90730-2
发表时间：
1992-05-01
期刊：
BONE AND MINERAL
影响因子：
--
作者：
ALI, SY
通讯作者：
ALI, SY
影响因子：
6.2
作者：
Chen, Neal X.;O'Neill, Kalisha D.;Moe, Sharon M.
通讯作者：
Moe, Sharon M.
影响因子：
3.4
作者：
Balcerzak, Marcin;Malinowska, Agata;Pikula, Slawomir
通讯作者：
Pikula, Slawomir