Children with ASD show links between aberrant sound processing, social symptoms, and atypical auditory interhemispheric and thalamocortical functional connectivity.
Children with ASD show links between aberrant sound processing, social symptoms, and atypical auditory interhemispheric and thalamocortical functional connectivity.
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DOI：
10.1016/j.dcn.2017.01.007
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发表时间：
2018-01
影响因子：
4.7
通讯作者：
Müller RA
中科院分区：
文献类型：
--
作者：
Linke AC;Jao Keehn RJ;Pueschel EB;Fishman I;Müller RA
ASD的听觉处理缺陷与社会和行为症状相关。大脑半球间连通性降低，感觉症状更严重。大脑半球间连通性降低的个体的言语智商较低。丘脑皮质过度连接可能会弥补感觉和社交缺陷。自闭症谱系障碍(ASD)是一种复杂而普遍的神经发育障碍，其特征是社交和沟通障碍，以及重复行为和对感觉刺激的非典型敏感性。网络连通性的改变已被广泛认识，但它们与社交和感官症状的相互作用在很大程度上仍不清楚。在这里，功能磁共振成像以及诊断和行为评估在患有ASD的儿童和青少年(n=40)和匹配的典型发育中的对照组(TD，n=38)的儿童和青少年中被使用，以检查听觉处理、大脑半球和丘脑皮质网络连接以及社会行为症状严重程度之间的关系。我们发现，声音的非典型加工与社交、认知和交流障碍有关。此外，感觉加工缺陷的严重程度和言语智商的降低与ASD患者听觉皮质的大脑半球间连通性降低有关。然而，ASD患者丘脑和听觉皮质之间的连接增加与认知和行为症状的减少有关，这表明丘脑皮质过度连接可能反映了ASD的一种代偿机制。这些发现为听觉感觉缺陷与社交和交流障碍之间的联系提供了新的证据。
Auditory processing deficits in ASD correlate with social and behavioral symptoms. Reduced interhemispheric connectivity is found with more severe sensory symptoms. Verbal IQ is lower in individuals with reduced interhemispheric connectivity. Thalamocortical overconnectivity may compensate for sensory and social deficits. Autism spectrum disorder (ASD) is a complex and prevalent neurodevelopmental disorder characterized by social and communicative deficits, as well as repetitive behaviors and atypical sensitivity to sensory stimulation. Alterations in network connectivity are widely recognized, but their interplay with social and sensory symptoms remains largely unclear. Here, functional magnetic resonance imaging and diagnostic and behavioral assessments were used in a cohort of children and adolescents with ASD (n = 40) and matched typically developing (TD, n = 38) controls to examine the relation between auditory processing, interhemispheric and thalamocortical network connectivity, and social-behavioral symptom severity. We found that atypical processing of sounds was related to social, cognitive, and communicative impairments. Additionally, severity of sensory processing deficits and lower verbal IQ were related to reduced interhemispheric connectivity of auditory cortices in ASD. Increased connectivity between the thalamus and auditory cortex in ASD, however, was associated with reduced cognitive and behavioral symptomatology, suggesting that thalamocortical overconnectivity might reflect a compensatory mechanism in ASD. These findings provide novel evidence for links between auditory sensory deficits and impairments in social interaction and communication.
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影响因子：
3.1
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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