Testing a breast cancer prevention and a multiple disease prevention weight loss programme amongst women within the UK NHS breast screening programme-a randomised feasibility study.
Testing a breast cancer prevention and a multiple disease prevention weight loss programme amongst women within the UK NHS breast screening programme-a randomised feasibility study.
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DOI：
10.1186/s40814-021-00947-4
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发表时间：
2021-12-20
影响因子：
1.7
通讯作者：
Evans DG
中科院分区：
文献类型：
--
作者：
Harvie M;French DP;Pegington M;Cooper G;Howell A;McDiarmid S;Lombardelli C;Donnelly L;Ruane H;Sellers K;Barrett E;Armitage CJ;Evans DG
超重和不健康行为（例如久坐不动、酗酒）在女性（包括参加乳房筛查的女性）中很常见。这些因素增加了患乳腺癌和其他疾病的风险。我们测试了为降低乳腺癌风险而制定的减肥/行为改变计划（乳腺癌预防计划，BCPP）与为降低乳腺癌，心血管疾病（CVD）和糖尿病（T2 D）风险而制定的计划（多种疾病预防计划，MDPP）的可行性和可接受性。在NHS乳腺筛查计划（NHSBSP）中，年龄在47-73岁的超重或肥胖女性（n = 1356）被随机（1：2）邀请参加BCPP或MDPP。BCPP包括关于乳腺癌风险的个性化信息以及网络和电话减肥/行为改变干预。MDPP还包括NHS健康检查（血脂、血压、HbA 1c和CVD [QRISK 2]和T2 D [QDiabetes和HbA 1c]风险的个性化反馈）。主要结局是摄取和保留以及其他可行性结局，包括干预保真度和高CVD和T2 D风险的患病率。次要结局包括体重变化。BCPP和MDPP的摄取率相当：45/508（9%）vs. 81/848（10%）和12个月保留率; 33/45（73%）vs. 53/81（65%）。这两个方案都具有很高的交付保真度，在12个月期间，每名妇女平均（95% CI）收到90（88-98%）预定电话，91（86-95%）预定电子邮件和89（76-102）网站条目。MDPP确定了15%的女性既往未知的10年CVD QRISK 2 ≥ 10%，56%的女性10年Q糖尿病风险≥ 10%。两组的体重减轻程度相当：BCPP 26/45（58%）和MDPP 46/81（57%），使用基线观察值结转插补，12个月时体重减轻超过5%。这两个方案似乎都是可行的。MDPP确定了以前未知的CVD和T2 D风险因素，但似乎没有增加参与行为改变超过标准BCPP参加乳腺癌筛查的妇女。可接受的摄取和保留以及良好的体重减轻支持BCPP的未来明确有效性试验。 ISRCTN 91372184，2014年9月28日注册。在线版本包含补充材料，可通过10.1186/s40814-021-00947-4获得。
Excess weight and unhealthy behaviours (e.g. sedentariness, high alcohol) are common amongst women including those attending breast screening. These factors increase the risk of breast cancer and other diseases. We tested the feasibility and acceptability of a weight loss/behaviour change programme framed to reduce breast cancer risk (breast cancer prevention programme, BCPP) compared to one framed to reduce risk of breast cancer, cardiovascular disease (CVD) and diabetes (T2D) (multiple disease prevention programme, MDPP). Women aged 47-73 years with overweight or obesity (n = 1356) in the NHS Breast Screening Programme (NHSBSP) were randomised (1:2) to be invited to join a BCPP or a MDPP. The BCPP included personalised information on breast cancer risk and a web and phone weight loss/behaviour change intervention. The MDPP also included an NHS Health Check (lipids, blood pressure, HbA1c and personalised feedback for risk of CVD [QRISK2] and T2D [QDiabetes and HbA1c]). Primary outcomes were uptake and retention and other feasibility outcomes which include intervention fidelity and prevalence of high CVD and T2D risk. Secondary outcomes included change in weight. The BCPP and MDPP had comparable rates of uptake: 45/508 (9%) vs. 81/848 (10%) and 12-month retention; 33/45 (73%) vs. 53/81 (65%). Both programmes had a high fidelity of delivery with receipt of mean (95% CI) 90 (88-98% of scheduled calls, 91 (86-95%) of scheduled e-mails and 89 (76-102) website entries per woman over the 12-month period. The MDPP identified 15% of women with a previously unknown 10-year CVD QRISK2 of ≥ 10% and 56% with 10-year Qdiabetes risk of ≥ 10%. Both groups experienced good comparable weight loss: BCPP 26/45 (58%) and MDPP 46/81 (57%) with greater than 5% weight loss at 12 months using baseline observation carried forward imputation. Both programmes appeared feasible. The MDPP identified previously unknown CVD and T2D risk factors but does not appear to increase engagement with behaviour change beyond a standard BCPP amongst women attending breast screening. A future definitive effectiveness trial of BCPP is supported by acceptable uptake and retention, and good weight loss. ISRCTN91372184, registered 28 September 2014. The online version contains supplementary material available at 10.1186/s40814-021-00947-4.
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DOI：
10.1097/01.alc.0000164374.32229.a2
发表时间：
2005-05-01
期刊：
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
影响因子：
--
作者：
Dawson, DA;Grant, BF;Zhou, Y
通讯作者：
Zhou, Y
乳腺癌的风险在筛查来自英国曼彻斯特的亚洲和白人英国/爱尔兰妇女的群体中。
影响因子：
4.5
作者：
Evans DG;Brentnall AR;Harvie M;Astley S;Harkness EF;Stavrinos P;Donnelly LS;Sampson S;Idries F;Watterson D;Cuzick J;Wilson M;Jain A;Harrison F;Maxwell AJ;Howell A
通讯作者：
Howell A
影响因子：
4
作者：
Evans, D. Gareth;Harvie, Michelle;Howell, Anthony
通讯作者：
Howell, Anthony
影响因子：
3.8
作者：
Harvie, M;Howell, A;Sellers, TA
通讯作者：
Sellers, TA
影响因子：
168.9
作者：
Bray, G. A.;Chatellier, A.;Duncan, C.;Greenway, F. L.;Levy, E.;Ryan, D. H.;Polonsky, K. S.;Tobian, J.;Ehrmann, D.;Matulik, M. J.;Clark, B.;Czech, K.;DeSandre, C.;Hilbrich, R.;McNabb, W.;Semenske, A. R.;Goldstein, B. J.;Smith, K. A.;Wildman, W.;Pepe, C.;Goldberg, R. B.;Calles, J.;Ojito, J.;Castillo-Florez, S.;Florez, H. J.;Giannella, A.;Lara, O.;Veciana, B.;Haffner, S. M.;Montez, M. G.;Lorenzo, C.;Martinez, A.;Hamman, R. F.;Testaverde, L.;Bouffard, A.;Dabelea, D.;Jenkins, T.;Lenz, D.;Perreault, L.;Price, D. W.;Steinke, S. C.;Horton, E. S.;Poirier, C. S.;Swift, K.;Caballero, E.;Jackson, S. D.;Lambert, L.;Lawton, K. E.;Ledbury, S.;Kahn, S. E.;Montgomery, B. K.;Fujimoto, W.;Knopp, R. H.;Lipkin, E. W.;Marr, M.;Murillo, A.;Trence, D.;Kitabchi, A. E.;Murphy, M. E.;Applegate, W. B.;Bryer-Ash, M.;Dagogo-Jack, S.;Frieson, S. L.;Lambeth, H.;Lichtermann, L. C.;Otkaei, H.;Rutledge, L. M. K.;Sherman, A. R.;Smith, C. M.;Soberman, J. E.;Williams-Cleaves, B.;Metzger, B. E.;Molitch, M. E.;Johnson, M. K.;Giles, M. M.;Larsen, D.;Niznik, C.;Pen, S. C.;Schinleber, P. A.;Nathan, D. M.;McKitrick, C.;Turgeon, H.;Abbott, K.;Altshuler, D.;Anderson, E.;Bissett, L.;Cagliero, E.;D'Anna, K.;Delahanty, L.;Florez, J. C.;Goldman, V.;Poulos, A.;Tseng, B.;Barrett-Connor, E.;Carrion-Petersen, M. L.;Horne, J.;Leos, D.;Mudaliar, S.;Smith, J.;Vejvoda, K.;Pi-Sunyer, F. X.;Lee, J. E.;Foo, S. T.;Hagamen, S.;Marrero, D. G.;Kelly, S. M.;Ackermann, R. T.;Fineberg, E. S.;Hadden, A.;Jackson, M. A.;Kirkman, M. S.;Mather, K. J.;Roach, P. J.;Wheeler, M. L.;Ratner, R. E.;Aroda, V.;Shapiro, S.;Bavido-Arrage, C.;Gibbs, P.;Uwaifo, Gl;Wiggins, R.;Saad, M. F.;Watson, K.;Botrous, M.;Jinagouda, S.;Budget, M.;Conzues, C.;Magpuri, P.;Ngo, K.;Xapthalamous, K.;White, N. H.;Das, S.;Santiago, A.;Brown, A. L.;Wernimont, C.;Saudek, C. D.;Whittington, T.;Clark, J. M.;Greene, A.;Jiggetts, D.;Mosley, H.;Reusing, J.;Rubin, R. R.;Stephen, S.;Utsey, E.;Schade, D. S.;Adams, K. S.;Hemphill, C.;Hyde, P.;Butler, L.;Canady, J. L.;Colleran, K.;Gonzales, Y.;Hernandez-McGinnis, D. A.;Katz, P.;King, C.;Crandall, J.;Brown-Friday, J. O.;Adorno, E.;Duffy, H.;Martinez, H.;Pompi, D.;Shamoon, H.;Walker, E. A.;Wylie-Rosett, J.;Orchard, T.;Jeffries, S.;Kramer, M. K.;Smith, M.;Kriska, A.;Pettigrew, J.;Semler, L.;Venditti, E.;Weinzierl, V.;Arakaki, R. F.;Baker-Ladao, N. K.;Isonaga, M. K.;Bermudez, N. E.;Mau, M. K.;Knowler, W. C.;Cooeyate, N.;Hoskin, M. A.;Natewa, C.;Percy, C. A.;Acton, K. J.;Andre, V. L.;Begay, S.;Bucca, B. C.;Cook, S.;Doughty, M. S.;Glass, J.;Glass, M.;Hanson, R. L.;Hassenpflug, D.;Ingraham, L. E.;Kobus, K. M.;Krakoff, J.;Manus, C.;McCabe, C.;Michaels, S.;Morgan, T.;Nelson, J. A.;Roy, R. J.;Smart, M.;Tonemah, D. P.;Wilson, C.;Fowler, S.;Brenneman, T.;Abebe, S.;Bamdad, J.;Callaghan, J.;Christophi, C. A.;Edelstein, S. L.;Gao, Y.;Gooding, R.;Gottlieb, A.;Grover, N.;Hoffman, H.;Jablonski, K.;Katz, R.;Kolinjivadi, P.;Lachin, J. M.;Ma, Y.;Reamer, S.;Sapozhnikova, A.;Sherif, H.;Temprosa, M.;Venditti, E. M.;Kriska, A. M.;Semler, L.;Weinzierl, V.;Marcovina, S.;Strylewicz, G.;Albers, J.;Prineas, R. J.;Alexander, T.;Campbell, C.;Hall, S.;Hensley, S.;Li, Y.;Mills, M.;Soliman, E.;Zhang, Z.;Fradkin, J.;Garfield, S.;Mayer-Davis, E.;Moran, R. R.;Ganiats, T.;Sarkin, A. J.
通讯作者：
Sarkin, A. J.