Breast cancer risk in a screening cohort of Asian and white British/Irish women from Manchester UK.
Breast cancer risk in a screening cohort of Asian and white British/Irish women from Manchester UK.
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乳腺癌的风险在筛查来自英国曼彻斯特的亚洲和白人英国/爱尔兰妇女的群体中。
DOI：
10.1186/s12889-018-5090-9
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发表时间：
2018-01-25
影响因子：
4.5
通讯作者：
Howell A
中科院分区：
文献类型：
--
作者：
Evans DG;Brentnall AR;Harvie M;Astley S;Harkness EF;Stavrinos P;Donnelly LS;Sampson S;Idries F;Watterson D;Cuzick J;Wilson M;Jain A;Harrison F;Maxwell AJ;Howell A
在英国参加筛查的白色英国/爱尔兰和亚洲妇女的乳腺癌风险因素之间的差异没有很好的记录。在2009年至2015年期间，来自大曼彻斯特的筛查队列自我识别了种族和传统乳腺癌风险因素，并随访至2016年。使用年龄标准化统计（欧洲标准人群）比较风险因素和发病率。招募了879名亚洲女性和51,779名年龄在46-73岁之间的未受影响的白色英国/爱尔兰女性。与白色英国/爱尔兰女性相比，亚洲女性的激素和生殖风险因素预测乳腺癌风险较低（平均10年风险2.6% vs 3.1%，差异0.4%，95%CI 0.3-0.5%）。白色英国/爱尔兰女性更有可能在初潮时年龄较小，超重或肥胖，身高较高，使用激素替代疗法，没有孩子。然而，尽管亚洲妇女体重较轻，但从20岁起体重增加较多，而且不太可能进行适度的体育活动。亚洲女性的乳房X光密度也略高。亚裔年龄标准化发病率为3.2（95%CI 1.6-5.2，18例癌症）/1000名女性/年，而白色英国/爱尔兰女性为4.5（95%CI 4.2-4.8，1076例癌症）。在大曼彻斯特参加筛查的亚裔女性患乳腺癌的风险可能比白色英国/爱尔兰女性低，但她们从事的体力活动更少，成年后体重增加更多。本文的在线版本（10.1186/s12889-018-5090-9）包含补充材料，可供授权用户使用。
The differences between breast cancer risk factors in white British/Irish and Asian women attending screening in the UK are not well documented. Between 2009-15 ethnicity and traditional breast cancer risk factors were self-identified by a screening cohort from Greater Manchester, with follow up to 2016. Risk factors and incidence rates were compared using age-standardised statistics (European standard population). Eight hundred and seventy-nine Asian women and 51,779 unaffected white British/Irish women aged 46-73 years were recruited. Asian women were at lower predicted breast cancer risk from hormonal and reproductive risk factors than white British/Irish women (mean 10 year risk 2.6% vs 3.1%, difference 0.4%, 95%CI 0.3-0.5%). White British/Irish women were more likely to have had a younger age at menarche, be overweight or obese, taller, used hormone replacement therapy and not to have had children.. However, despite being less overweight Asian women had gained more weight from age 20 years and were less likely to undertake moderate physical activity. Asian women also had a slightly higher mammographic density. Asian age-standardised incidence was 3.2 (95%CI 1.6-5.2, 18 cancers) per thousand women/year vs 4.5 (95%CI 4.2-4.8, 1076 cancers) for white British/Irish women. Asian women attending screening in Greater Manchester are likely to have a lower risk of breast cancer than white British/Irish women, but they undertake less physical activity and have more adult weight gain. The online version of this article (10.1186/s12889-018-5090-9) contains supplementary material, which is available to authorized users.
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英国乳腺癌发病率的种族差异是由于已知的该疾病危险因素的差异造成的：前瞻性研究。
影响因子：
8.8
作者：
Gathani, T.;Ali, R.;Balkwill, A.;Green, J.;Reeves, G.;Beral, V.;Moser, K. A.
通讯作者：
Moser, K. A.
影响因子：
254.7
作者：
Parkin, DM;Bray, F;Pisani, P
通讯作者：
Pisani, P
影响因子：
8.8
作者：
Bansal, N.;Bhopal, R. S.;Brewster, D. H.
通讯作者：
Brewster, D. H.
影响因子：
2
作者：
Tyrer, J;Duffy, SW;Cuzick, J
通讯作者：
Cuzick, J
影响因子：
10.3
作者：
ZIEGLER, RG;HOOVER, RN;HYER, MB
通讯作者：
HYER, MB