Activity manipulation of an excitatory interneuron, during an embryonic critical period, alters network tuning of the Drosophila larval locomotor circuit
Activity manipulation of an excitatory interneuron, during an embryonic critical period, alters network tuning of the Drosophila larval locomotor circuit
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在胚胎关键期，兴奋性中间神经元的活动操纵改变了果蝇幼虫运动回路的网络调谐
DOI：
10.1101/780221
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Giachello C
中科院分区：
文献类型：
--
作者：
Giachello C
随着神经系统的发育，在关键时期的活动扰动可能会导致永久性的网络功能改变。然而，活动扰动如何影响单个突触，网络响应和潜在的信号机制还没有很好地理解。在这里，我们利用最近确定的关键时期的theDrosophilarval运动电路的发展表明，活动扰动差异影响个人和确定的突触配对。值得注意的是，我们进一步表明，选择性兴奋性中间神经元的活动操纵足以完全概括由网络范围的活动干扰引起的影响;这表明一些神经元对网络调谐做出了更大的贡献。我们确定一氧化氮（NO）信号作为一个潜在的中介活动依赖性网络调谐在关键时期。重要的是，NO信令对网络调谐的影响由网络的先前活动状态决定。因此，这项研究提供了目前缺乏的机制洞察力，以了解关键时期的活动如何调整发展中的网络。
As nervous systems develop, activity perturbations during critical periods can lead to permanently altered network function. However, how activity perturbation influences individual synapses, the network response and the underlying signalling mechanisms are not well understood. Here, we exploit a recently identified critical period in the development of theDrosophilalarval locomotor circuit to show that activity perturbation differentially affects individual and identified synaptic pairings. Remarkably, we further show that activity-manipulation of a selective excitatory interneuron is sufficient to fully recapitulate the effects induced by network-wide activity disturbance; indicative that some neurons make a greater contribution to network tuning. We identify nitric oxide (NO)-signalling as a potential mediator of activity-dependent network tuning during the critical period. Significantly, the effect of NO-signalling to network tuning is dictated by the prior activity state of the network. Thus, this study provides mechanistic insight that is currently lacking into how activity during a critical period tunes a developing network.
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影响因子：
4.6
作者：
Marley R;Giachello CN;Scrutton NS;Baines RA;Jones AR
通讯作者：
Jones AR
复杂刺激引起的视觉反射性癫痫发作
影响因子：
5.6
作者：
B. Zifkin;Y. Inoue
通讯作者：
Y. Inoue
影响因子：
3.7
作者：
Streit AK;Fan YN;Masullo L;Baines RA
通讯作者：
Baines RA
影响因子：
2.5
作者：
Krishnan, Giri P.;Filatov, Gregory;Bazhenov, Maxim
通讯作者：
Bazhenov, Maxim
DOI：
10.1073/pnas.88.24.11285
发表时间：
1991-12-01
影响因子：
11.1
作者：
ODELL, TJ;HAWKINS, RD;ARANCIO, O
通讯作者：
ARANCIO, O