Ethnic differences in smoking intensity and COPD risk: an observational study in primary care.
Ethnic differences in smoking intensity and COPD risk: an observational study in primary care.
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DOI：
10.1038/s41533-017-0052-8
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发表时间：
2017-09-04
影响因子：
3.1
通讯作者：
White P
中科院分区：
文献类型：
--
作者：
Gilkes A;Hull S;Durbaba S;Schofield P;Ashworth M;Mathur R;White P
在调整年龄、性别、贫困和吸烟状况后，黑人和南亚人患慢性阻塞性肺病的风险低于白色人。吸烟强度的作用是评估其对慢性阻塞性肺疾病风险的种族差异的贡献，这种关系以前没有研究过。这项横断面研究包括从四个多民族伦敦行政区常规收集的初级保健数据。吸烟强度（估计每天的香烟）进行了比较种族群体之间。采用多元逻辑回归分析比较不同种族人群的慢性阻塞性肺疾病风险，控制年龄、性别、剥夺、哮喘以及吸烟状况和吸烟强度，并进行独立检查。总共有1，000，388名成年人被纳入。白色英国人/爱尔兰人组的吸烟率和吸烟强度明显高于其他种族组。吸烟强度越高，患慢性阻塞性肺疾病的风险越高。在调整吸烟状况或吸烟强度后，与白色英国人/爱尔兰人相比，所有种族组的慢性阻塞性肺疾病风险均显著降低，非洲黑人的风险最低（比值比0.33;置信区间0.28-0.38）。在这项研究中，慢性阻塞性肺疾病风险的种族差异不能用吸烟率或吸烟强度的种族差异来解释。应寻找慢性阻塞性肺疾病风险种族差异的其他原因，包括吸烟行为、环境因素、反复呼吸道感染、移民身份、尼古丁代谢和成瘾性以及对香烟烟雾有害影响的不同易感性方面的种族差异。黑人和南亚人的吸烟强度较低并不能解释他们患慢性阻塞性肺疾病（COPD）的风险较低。由伦敦国王学院的亚历山大吉尔克斯领导的一个英国研究小组分析了来自英国首都四个多民族自治区的100多万人的初级保健数据。研究人员发现，白色英国人或爱尔兰人的吸烟状况和强度（以每天吸烟的数量衡量）都明显高于其他种族人群。然而，即使在对吸烟状况或吸烟强度进行统计调整后，研究人员也无法解释南亚或非洲血统的人患COPD的患病率要低得多的事实，COPD是一种与吸烟有关的肺部疾病。研究结果表明，种族差异的其他解释仍然需要。
Chronic obstructive pulmonary disease risk is lower in black and south Asian people than white people, when adjusting for age, sex, deprivation and smoking status. The role of smoking intensity was assessed for its contribution to ethnic differences in chronic obstructive pulmonary disease risk, a relationship not previously investigated. This cross-sectional study included routinely collected primary care data from four multi-ethnic London boroughs. Smoking intensity (estimated by cigarettes per day) was compared between ethnic groups. Chronic obstructive pulmonary disease risk was compared between ethnic groups using multiple logistic regression, controlling for age, sex, deprivation, asthma and both smoking status and smoking intensity, examined independently. In all, 1,000,388 adults were included. Smoking prevalence and intensity were significantly higher in the white British/Irish groups than other ethnic groups. Higher smoking intensity was associated with higher chronic obstructive pulmonary disease risk. Chronic obstructive pulmonary disease risk was significantly lower in all ethnic groups compared with white British/Irish after adjustment for either smoking status or smoking intensity, with lowest risk in black Africans (odds ratio 0.33; confidence interval 0.28–0.38). Ethnic differences in chronic obstructive pulmonary disease risk were not explained in this study by ethnic differences in smoking prevalence or smoking intensity. Other causes of ethnic differences in chronic obstructive pulmonary disease risk should be sought, including ethnic differences in smoking behaviour, environmental factors, repeated respiratory infections, immigrant status, metabolism and addictiveness of nicotine and differential susceptibility to the noxious effects of cigarette smoke. Lower smoking intensity among blacks and south Asians does not explain their lower risk for chronic obstructive pulmonary disease (COPD). A UK team led by Alexander Gilkes from Kings College London analysed primary care data from more than a million people living in four multi-ethnic boroughs of the British capital. The researchers found that smoking status and intensity (as measured by number of cigarettes smoked per day) were both significantly higher in white British or Irish groups than in other ethnic populations. Even after statistically adjusting for smoking status or smoking intensity, however, the researchers couldn’t account for the fact that people of south Asian or African descent had much lower prevalence rates of COPD, a lung disease linked to smoking. The findings suggest that other explanations of ethnic differences are still needed.
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影响因子：
3.1
作者：
通讯作者：
--
影响因子：
6.7
作者：
HERNING, RI;JONES, RT;MINES, AH
通讯作者：
MINES, AH
影响因子：
5.2
作者：
El-Zaatari ZM;Chami HA;Zaatari GS
通讯作者：
Zaatari GS
影响因子：
5.9
作者：
Macleod, John;Robertson, Roy;Reid, Peter
通讯作者：
Reid, Peter
影响因子：
6
作者：
Bernaards, CM;Twisk, JWR;Kemper, HCG
通讯作者：
Kemper, HCG