Rapid eradication of antibiotic-resistant bacteria and biofilms by MXene and near-infrared light through photothermal ablation

Rapid eradication of antibiotic-resistant bacteria and biofilms by MXene and near-infrared light through photothermal ablation
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通过光热消融,MXene 和近红外光快速消灭抗生素耐药细菌和生物膜

DOI:
10.1007/s40843-020-1451-7
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发表时间:
2020-09
期刊:
SCIENCE CHINA Materials
影响因子:
--
通讯作者:
Weili Hong
Weili Hong
中科院分区:
其他
文献类型:
--
作者:
Fan Wu;Huiling Zheng;Wenzhao Wang;Qiong Wu;Qi Zhang;Jiayu Guo;Bangzheng Pu;Xinyuan Shi;Jiebo Li;Xiangmei Chen;Weili Hong

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随着抗菌素耐药性的发展和上升,迫切需要快速有效地杀死细菌,特别是对于通常难以用常规抗生素治疗的耐药细菌和细菌生物膜。在这里,通过MXene和光的光热消融展示了一种快速广谱抗菌策略。Ti3C2 MXenes在808 nm光作用下,仅20 min就显示出明显的抗菌效果。该抗菌策略对耐甲氧西林金黄色葡萄球菌(MRSA)和耐万古霉素肠球菌(VRE)等15种细菌有效。此外,快速抗菌策略对MRSA生物膜有效,通过破坏结构以及杀死生物膜中的细菌。此外,对Ti3C2的抑菌机理的研究表明,Ti3C2主要通过插入/接触和光热效应对细菌进行物理杀伤。这项工作拓宽了MXene的潜在应用,并提供了一种物理根除细菌和生物膜的方法,而不会产生耐药性。
With the development and rising of antimicrobial resistance, rapid and effective killings of bacteria are urgently needed, especially for antibiotic-resistant bacteria and bacterial biofilms that are usually hard to be treated with conventional antibiotics. Here, a rapid and broad-spectrum antibacterial strategy is demonstrated through photothermal ablation with MXene and light. Ti3C2 MXenes, when combined with 808 nm light, show significant antibacterial effects in just 20 min. The antibacterial strategy is effective to 15 bacterial species tested, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE). In addition, the rapid antibacterial strategy works for MRSA biofilms, by damaging the structures as well as killing bacteria in biofilms. Furthermore, the investigation of the antibacterial mechanisms shows that Ti3C2 with light kills bacteria mainly physically through inserting/contact and photothermal effect. This work broadens the potential applications of MXene and provides a way to eradicate bacteria and biofilms physically, without the likelihood of resistance development.
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