Therapeutic mesopore construction on 2D Nb(2)C MXenes for targeted and enhanced chemo-photothermal cancer therapy in NIR-II biowindow.
Therapeutic mesopore construction on 2D Nb(2)C MXenes for targeted and enhanced chemo-photothermal cancer therapy in NIR-II biowindow.
复制标题
二维 Nb2C MXene 上的治疗性介孔结构，用于 NIR-II 生物窗中的靶向和增强化学光热癌症治疗
作者：
Han X;Jing X;Yang D;Lin H;Wang Z;Ran H;Li P;Chen Y
二维（2D）MXene已成为一种有前途的平面治疗诊断纳米平台，用于多功能生物医学应用;但由于缺乏足够的表面工程所需的表面化学，它们的体内行为和性能受到严重影响和阻碍。为了解决这个关键问题，这项工作采用了多功能的溶胶-凝胶化学在2D碳化铌（Nb 2C）MXene表面上构建了一个独特的“治疗性中孔”层。研究方法：原位自组装的中孔制造剂（在这种情况下，十六烷基三甲基氯化铵）保持在中孔内用于有效的化疗。进一步采用介孔二氧化硅包覆的Nb 2C MXene的丰富的表面盐化学用于逐步表面工程，包括PEG化和与环状精氨酸-甘氨酸-天冬氨酸五肽c（RGDyC）缀合以用于靶向肿瘤积累。结果如下：基于2D Nb 2C MXene在近红外（NIR）-II生物窗口（1064 nm）中的光热转换能力（28.6%）选择2D Nb 2C MXene用于增强光热热疗。系统的体外和体内评估证明了这些介孔涂覆的2D Nb 2C MXenes在NIR-II生物窗中对癌症（U87癌细胞系和相应的肿瘤异种移植物;抑制效率：92.37%）的靶向和增强的化疗和光热热疗。结论：这项工作不仅大大拓宽了2D Nb 2C MXene在增强癌症治疗方面的生物医学应用，而且还为2D MXene的表面工程提供了一种有效的策略，以满足多方面的应用需求。
Two-dimensional (2D) MXenes have emerged as a promising planar theranostic nanoplatform for versatile biomedical applications; but their in vivo behavior and performance has been severely influenced and hindered by a lack of necessary surface chemistry for adequate surface engineering. To solve this critical issue, this work employs versatile sol-gel chemistry for the construction of a unique “therapeutic mesopore” layer onto the surface of 2D niobium carbide (Nb2C) MXene. Methods: The in situ self-assembled mesopore-making agent (cetanecyltrimethylammonium chloride, in this case) was kept within the mesopores for efficient chemotherapy. The abundant surface saline chemistry of mesoporous silica-coated Nb2C MXene was further adopted for stepwise surface engineering including PEGylation and conjugation with cyclic arginine-glycine-aspartic pentapeptide c(RGDyC) for targeted tumor accumulation. Results: 2D Nb2C MXenes were chosen based on their photothermal conversion capability (28.6%) in the near infrared (NIR)-II biowindow (1064 nm) for enhanced photothermal hyperthermia. Systematic in vitro and in vivo assessments demonstrate targeted and enhanced chemotherapy and photothermal hyperthermia of cancer (U87 cancer cell line and corresponding tumor xenograft; inhibition efficiency: 92.37%) in the NIR-II biowindow by these mesopore-coated 2D Nb2C MXenes. Conclusion: This work not only significantly broadens the biomedical applications of 2D Nb2C MXene for enhanced cancer therapy, but also provides an efficient strategy for surface engineering of 2D MXenes to satisfy versatile application requirements.
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影响因子：
16.6
作者：
Chou, Stanley S.;Kaehr, Bryan;Kim, Jaemyung;Foley, Brian M.;De, Mrinmoy;Hopkins, Patrick E.;Huang, Jiaxing;Brinker, C. Jeffrey;Dravid, Vinayak P.
通讯作者：
Dravid, Vinayak P.
影响因子：
29.4
作者：
Chen, Yu;Ye, Delai;Wang, Lianzhou
通讯作者：
Wang, Lianzhou
影响因子：
10.8
作者：
Jiang, Yuyan;Upputuri, Paul Kumar;Pu, Kanyi
通讯作者：
Pu, Kanyi
影响因子：
41.2
作者：
通讯作者：
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影响因子：
29.4
作者：
Chimene, David;Alge, Daniel L.;Gaharwar, Akhilesh K.
通讯作者：
Gaharwar, Akhilesh K.