Excitability and contractility in arterioles and venules from the urinary bladder.
Excitability and contractility in arterioles and venules from the urinary bladder.
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DOI：
10.1016/bs.ctm.2020.01.003
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发表时间：
2020
影响因子：
--
通讯作者：
Monson FC
中科院分区：
文献类型：
--
作者：
Tykocki NR;Monson FC
膀胱执行两个关键的生理功能：（1）储存尿液，以及（2）在适当的时间排尿。虽然这两个功能看起来很简单，但这两个过程都对膀胱血管系统施加了长时间的拉伸和压缩力，其强度大于任何其他中空器官中的血管。为了补偿这些力，膀胱脉管系统已经调整了几个关键特征，这些特征在膀胱充盈期间保持血液流动并防止排空期间的破坏性压力波动。本章首先介绍了膀胱血管系统的关键解剖特征，以及这些特征如何帮助维持膀胱功能环境中的血流。接下来，我们研究了膀胱小动脉兴奋性的调节机制，重点是肌源性张力的发展和调节。然后，我们讨论了膀胱毛细血管和微静脉的生理意义和兴奋性，以及它们在维持组织灌注中的重要作用。最后，膀胱血管的功能将在膀胱功能障碍方面进行探索，以了解与疾病相关的下尿路症状是否可以被认为是血管性的。还包括膀胱本身的观点，作为一个模型，用于了解缺血/再灌注损伤和膀胱的可能性，以减轻有害影响时，血流被阻塞，并迅速恢复到其他器官的关键。
The urinary bladder performs two key physiological functions: (1) to store urine, and (2) void urine at an appropriate time. While these two functions seem simple, both processes exert prolonged stretch and compressive forces on the urinary bladder vasculature that are greater than those seen by vessels in any other hollow organ. To compensate for these forces, the urinary bladder vasculature has adapted several key features that maintain blood flow during bladder filling and prevent damaging pressure fluctuations during emptying. This chapter first describes key anatomical features of the urinary bladder vasculature and how these features aid in maintaining blood flow in the milieu of the functioning bladder. Next, we investigate the mechanisms regulating excitability of urinary bladder arterioles with emphasis on the development and regulation of myogenic tone. We then discuss the physiological significance and excitability of urinary bladder capillaries and venules, and their important roles in maintaining tissue perfusion. Finally, the functionality of the urinary bladder vasculature will be explored in terms of bladder dysfunction, to understand if lower urinary tract symptoms associated with disease can be considered vascular in nature. Also included are perspectives on the urinary bladder itself as a model for understanding ischemia/reperfusion injury and the possibility that the urinary bladder holds a key to mitigating deleterious effects that result when blood flow is occluded and rapidly restored to other organs.
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影响因子：
6.1
作者：
Hanna-Mitchell, Ann T.;Beckel, Jonathan M.;Birder, Lori A.
通讯作者：
Birder, Lori A.
DOI：
10.1124/jpet.106.108902
发表时间：
2006-12-01
影响因子：
3.5
作者：
Fabiyi, Adebola C.;Brading, Alison F.
通讯作者：
Brading, Alison F.
影响因子：
5
作者：
Ghafar, MA;Anastasiadis, AG;Levin, RM
通讯作者：
Levin, RM
影响因子：
5.5
作者：
Ferguson, DR;Kennedy, I;Burton, TJ
通讯作者：
Burton, TJ
DOI：
10.1016/j.juro.2009.08.070
发表时间：
2009-12
期刊：
The Journal of urology
影响因子：
--
作者：
Daneshgari F;Liu G;Birder L;Hanna-Mitchell AT;Chacko S
通讯作者：
Chacko S