Frequency and distribution of primary site among gender minority cancer patients: An analysis of U.S. national surveillance data.
Frequency and distribution of primary site among gender minority cancer patients: An analysis of U.S. national surveillance data.
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DOI：
10.1016/j.canep.2018.02.008
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发表时间：
2018-06
影响因子：
2.6
通讯作者：
Goodman M
中科院分区：
文献类型：
--
作者：
Nash R;Ward KC;Jemal A;Sandberg DE;Tangpricha V;Goodman M
变性人和性发育障碍（DSD）患者是两类不同的性别少数群体，每一类都有独特的癌症风险因素。虽然癌症登记数据通常只包括两类性别，但登记员可以选择表明患者是变性人或患有DSD。46个州和哥伦比亚特区的原发性癌症病例数据来自1995-2013年期间的北美中央癌症登记协会（NAACCR）数据库。分别对变性人和DSD患者的原发部位和具有共同风险因素的癌症类别的分布进行了检查，并与男性和女性癌症患者中观察到的相应分布进行了比较。通过观察病例数除以预期病例数计算比例发生率。根据在男性和女性患者中观察到的每种癌症类别的诊断特异性病例的年龄和年份比例计算预期病例。与男性（2.3; 2.0-2.7）或女性（3.3; 2.8-3.7）相比，跨性别患者病毒感染诱发癌症的比例发病率（95%置信区间）显著升高。成年DSD患者的癌症部位分布与男性或女性患者相似，但DSD儿童的睾丸癌病例比预期多10倍（95%置信区间：4.7-20）。变性和DSD癌症患者中某些原发部位和恶性肿瘤类别的比例与男性或女性患者中观察到的比例不同。
Transgender people and persons with disorders of sex development (DSD) are two separate categories of gender minorities, each characterized by unique cancer risk factors. Although cancer registry data typically include only two categories of sex, registrars have the option of indicating that a patient is transgender or has a DSD. Data for primary cancer cases in 46 states and the District of Columbia were obtained from the North American Association of Central Cancer Registries (NAACCR) database for the period 1995–2013. The distributions of primary sites and categories of cancers with shared risk factors were examined separately for transgender and DSD patients and compared to the corresponding distributions observed in male and female cancer patients. Proportional incidence ratios were calculated by dividing the number of observed cases by the number of expected cases. Expected cases were calculated based on the age- and year of diagnosis-specific proportions of cases for each cancer category observed among male and female patients. Transgender patients have significantly elevated proportional incidence ratios (95% confidence intervals) for viral infection induced cancers compared to either males (2.3; 2.0–2.7) or females (3.3; 2.8–3.7). Adult DSD patients have a similar distribution of cancer sites compared to male or female patients but DSD children have ten times more cases of testicular cancer than expected (95% confidence interval: 4.7–20). The proportions of certain primary sites and categories of malignancies among transgender and DSD cancer patients are different from the proportions observed for male or female patients.
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DOI：
10.1016/j.ogc.2009.02.001
发表时间：
2009-03-01
影响因子：
3.2
作者：
Allen, Lisa
通讯作者：
Allen, Lisa
影响因子：
2.3
作者：
Pleskacova, J.;Hersmus, R.;Looijenga, L. H.
通讯作者：
Looijenga, L. H.
影响因子：
5.8
作者：
Cools, M.;Pleskacova, J.;Wolffenbuttel, K. P.
通讯作者：
Wolffenbuttel, K. P.
影响因子：
2
作者：
Jiang, Jian-Fa;Xue, Wei;Sun, Ai-Jun
通讯作者：
Sun, Ai-Jun
影响因子：
5.6
作者：
Silverberg, Michael J.;Nash, Rebecca;Goodman, Michael
通讯作者：
Goodman, Michael