Illuminating the oral microbiome and its host interactions: recent advancements in omics and bioinformatics technologies in the context of oral microbiome research.
Illuminating the oral microbiome and its host interactions: recent advancements in omics and bioinformatics technologies in the context of oral microbiome research.
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DOI：
10.1093/femsre/fuad051
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发表时间：
2023-09-05
影响因子：
11.3
通讯作者：
中科院分区：
文献类型：
--
作者：
口腔微生物群对人类健康有着巨大的影响，口腔菌群失调现在与许多口腔和全身疾病有关。测序、质谱、生物信息学、计算生物学和机器学习方面的最新进展正在彻底改变口腔微生物组研究，使得使用组学方法能够以前所未有的规模和分辨率水平进行分析。这篇综述全面介绍了当前可用于对（所有）微生物组进行基因组学、宏基因组学、系统基因组学、泛基因组学、转录组学、蛋白质组学、代谢组学、脂质组学和多组学分析的最先进工具，然后提供了如何将这些技术具体应用于口腔微生物组研究的示例。强调了这些研究的主要发现以及该领域仍然面临的挑战。尽管这里讨论的方法是在其对口腔微生物组研究的具体贡献的背景下进行的，但它们与任何微生物组的研究相关，并且其目标受众包括研究人员只是想了解微生物组学的介绍和/或最新组学方法的更新。使用组学方法对口腔微生物群进行持续研究至关重要，它将显着改善人类健康、寿命和生活质量。这篇综述提供了当前可用于对（所有）微生物组进行基因组学、宏基因组学、系统基因组学、泛基因组学、转录组学、蛋白质组学、代谢组学、脂质组学和多组学分析的最先进工具的全面视角，然后提供了如何将这些技术具体应用于口腔微生物组研究的示例。
The oral microbiota has an enormous impact on human health, with oral dysbiosis now linked to many oral and systemic diseases. Recent advancements in sequencing, mass spectrometry, bioinformatics, computational biology, and machine learning are revolutionizing oral microbiome research, enabling analysis at an unprecedented scale and level of resolution using omics approaches. This review contains a comprehensive perspective of the current state-of-the-art tools available to perform genomics, metagenomics, phylogenomics, pangenomics, transcriptomics, proteomics, metabolomics, lipidomics, and multi-omics analysis on (all) microbiomes, and then provides examples of how the techniques have been applied to research of the oral microbiome, specifically. Key findings of these studies and remaining challenges for the field are highlighted. Although the methods discussed here are placed in the context of their contributions to oral microbiome research specifically, they are pertinent to the study of any microbiome, and the intended audience of this includes researchers would simply like to get an introduction to microbial omics and/or an update on the latest omics methods. Continued research of the oral microbiota using omics approaches is crucial and will lead to dramatic improvements in human health, longevity, and quality of life. This review provides a comprehensive perspective of the current state-of-the-art tools available to perform genomics, metagenomics, phylogenomics, pangenomics, transcriptomics, proteomics, metabolomics, lipidomics, and multi-omics analysis on (all) microbiomes, and then provides examples of how the techniques have been applied to research of the oral microbiome, specifically.
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影响因子：
5.7
作者：
Bao K;Li X;Poveda L;Qi W;Selevsek N;Gumus P;Emingil G;Grossmann J;Diaz PI;Hajishengallis G;Bostanci N;Belibasakis GN
通讯作者：
Belibasakis GN
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4.8
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Baker JL
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Baker JL
影响因子：
14.9
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通讯作者：
Mardinoglu A
影响因子：
3.6
作者：
Torres PJ;Thompson J;McLean JS;Kelley ST;Edlund A
通讯作者：
Edlund A
影响因子：
7.7
作者：
Beghini F;McIver LJ;Blanco-Míguez A;Dubois L;Asnicar F;Maharjan S;Mailyan A;Manghi P;Scholz M;Thomas AM;Valles-Colomer M;Weingart G;Zhang Y;Zolfo M;Huttenhower C;Franzosa EA;Segata N
通讯作者：
Segata N