Four regions of allelic imbalance on 17q12‐qter associated with high‐grade breast tumors
Four regions of allelic imbalance on 17q12‐qter associated with high‐grade breast tumors
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17q12-qter 上四个等位基因失衡区域与高级别乳腺肿瘤相关
DOI：
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
G. Casey
中科院分区：
文献类型：
--
作者：
S. Plummer;M. J. Paris;J. Myles;R. Tubbs;J. Crowe;G. Casey
17号染色体重排或丢失在乳腺肿瘤中是常见的事件。17号染色体至少包含四个与乳腺癌相关的基因(TP53、ERBB2(Her2/neu)、BRCA1和NM23)，以及其他可能与杂合性丢失或等位基因失衡研究有关的抑癌基因和癌基因。等位基因失衡是指肿瘤样本中遗传物质的增加或丢失，为肿瘤相关基因的定位提供间接证据。我们分析了一组85对乳腺肿瘤/正常组织，其中21个基于PCR的短串联重复(STR)标记位于17q12-QTER，以更准确地定义等位基因不平衡区域，并确定它们与临床参数的关系。我们的分析揭示了至少四个常见的等位基因失衡区域：BRCA1近端，包括D17S800(17q12)；NM23远端，D17S787附近(17q22)；生长激素(GH)基因座附近，D17S948(17q23-24)；以及标记D17S937和D17S802(17q25)之间。这些数据还表明，17q遗传物质的丢失(或获得)与低分化(III级)肿瘤(P=0.001)、高S期细胞比例(P=0.034)和免疫组织化学TP53阳性(P=0.011)相关。然而，类固醇受体状态、ERBB2(Her2/neu)染色和非整倍体与17q的等位基因失衡无关。基因染色体癌20：354-362,1997。©1997 Wiley-Liss，Inc.
Rearrangements or loss of chromosome 17 are frequent events in breast tumors. Chromosome 17 contains at least four genes implicated in breast cancer (TP53, ERBB2 (Her2/neu), BRCA1, and NM23), as well as other putative tumor suppressor genes and oncogenes implicated in loss of heterozygosity or allelic imbalance studies. Allelic imbalance represents the addition or loss of genetic material in tumor samples, providing circumstantial evidence for the location of cancer related genes. We have analyzed a panel of 85 breast tumor/normal tissue pairs with 21 PCR‐based short tandem repeat (STR) markers located at 17q12‐qter to more precisely define regions of allelic imbalance and to determine their relation to clinical parameters. Our analysis revealed at least four common regions of allelic imbalance: proximal to BRCA1, including D17S800 (17q12); distal to NM23 around D17S787 (17q22); near the growth hormone (GH) locus, at D17S948 (17q23‐24); and between markers D17S937 and D17S802 (17q25). These data also reveal that loss (or gain) of 17q genetic material correlates with poorly differentiated (grade III) tumors (P = <0.001), high S phase fraction (P = 0.034), and positive TP53 immunohistochemical staining (P = 0.011). However, steroid receptor status, ERBB2 (Her2/neu) staining, and aneuploidy do not correlate with allelic imbalance at 17q. Genes Chromosomes Cancer 20:354–362, 1997. © 1997 Wiley‐Liss, Inc.
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影响因子：
56.9
作者：
FUTREAL, PA;LIU, QY;WISEMAN, R
通讯作者：
WISEMAN, R
DOI：
10.1093/jnci/85.3.200
发表时间：
1993-02-03
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
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作者：
ALLRED, DC;CLARK, GM;MCGUIRE, WL
通讯作者：
MCGUIRE, WL
人类 17 号和 11 号染色体对乳腺癌和前列腺癌转移的差异抑制。
影响因子：
11.2
作者：
Rinker-Schaeffer,CW;Hawkins,AL;Ru,N;Dong,J;Stoica,G;Griffin,CA;Ichikawa,T;Barrett,JC;Isaacs,JT
通讯作者：
Isaacs,JT
将 228 个 EST 和 26 个基因映射到人类 17 号染色体的综合物理和遗传图谱中。
DOI：
10.1006/geno.1997.4906
发表时间：
1997
期刊：
Genomics.
影响因子：
--
作者：
Plummer,SJ;Simmons,JA;Adams,L;Casey,G
通讯作者：
Casey,G
影响因子：
56.9
作者：
HOLLSTEIN, M;SIDRANSKY, D;HARRIS, CC
通讯作者：
HARRIS, CC