Occupational trichloroethylene exposure and antinuclear antibodies: a cross-sectional study in China.
Occupational trichloroethylene exposure and antinuclear antibodies: a cross-sectional study in China.
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DOI：
10.1136/oemed-2022-108266
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发表时间：
2022-10
影响因子：
4.9
通讯作者：
中科院分区：
文献类型：
--
作者：
人们一直担心接触三氯乙烯(TCE)可能导致自身免疫性疾病，三氯乙烯是一种工业溶剂，也是危险废物场地附近的常见污染物。对三氯乙烯暴露的狼疮易感小鼠品系的研究报告了血清抗核抗体(ANA)(自身免疫的标志)和自身免疫病理变化的增加，而流行病学研究对三氯乙烯暴露与硬皮病之间的联系提供的支持有限。为了探讨人体自身免疫的暴露相关生物学证据，我们测定了广东中国接触三氯乙烯工人(n=80)和非接触者(n=96)血清中ANA水平。在采血前对三氯乙烯进行全班个人空气暴露测量。Hep-2细胞免疫荧光法检测血清ANA。我们使用多变量Logistic回归计算了与三氯乙烯暴露水平(以三氯乙烷为切入点进行分类)和ANA阳性(1：320稀释时1+强度)相关的优势比(OR)和95%可信区间(CI)。176名参与者中有16名样本ANA呈阳性。我们发现，与未暴露的对照组相比，较高水平的TCE暴露(浓度为17.27ppm)与ANA阳性的几率(OR 4.7，95%可信区间1.3-16.8)相关。排除两名诊断为自身免疫性疾病的受试者后，这种关联仍然存在(OR 4.5，95%CI 1.2-16.2)。在较低的暴露水平下，我们没有观察到与ANAS的关联。我们的发现，据我们所知，第一个直接的人类证据，三氯乙烯暴露和全身自身免疫之间的联系，为三氯乙烯和自身免疫性疾病的流行病学证据提供了生物学上的可信。
There has been concern over the possible risk of autoimmune diseases from exposure to trichloroethylene (TCE), an industrial solvent and common pollutant near hazardous waste sites. Studies of TCE-exposed lupus-prone mouse strains have reported increases in serum antinuclear antibodies (ANAs), a marker of autoimmunity, and autoimmune pathologic changes, while epidemiologic studies have provided limited support for an association between TCE exposure and scleroderma. To investigate exposure-related biologic evidence of autoimmunity in humans, we measured ANA levels in sera from a cross-sectional study of TCE-exposed (n=80) and unexposed (n=96) workers in Guangdong, China. Full-shift personal air exposure measurements for TCE were taken prior to blood collection. Serum ANAs were detected by immunofluorescence on HEp-2 cells. We calculated odds ratios (ORs) and 95% confidence intervals (CI) relating levels of TCE exposure (categorized using tertiles as cut-points) and ANA positivity (1+ intensity at 1:320 dilution) using multivariable logistic regression. Samples from 16 of 176 participants were ANA-positive. We found higher levels of TCE exposure (concentrations > 17.27 ppm) to be associated with an elevated odds of ANA positivity (OR 4.7, 95% CI 1.3–16.8) compared to unexposed controls. This association remained after excluding two subjects with diagnosed autoimmune disease (OR 4.5, 95% CI 1.2–16.2). We did not observe an association with ANAs at lower exposure levels. Our findings, to our knowledge the first direct human evidence of an association between TCE exposure and systemic autoimmunity, provide biologic plausibility to epidemiologic evidence relating TCE and autoimmune disease.
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影响因子：
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DOI：
10.1016/j.curtheres.2014.06.004
发表时间：
2014-12
影响因子：
1.9
作者：
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Li, Hong-Xing