The role of lipids in exosome biology and intercellular communication: Function, analytics and applications.
The role of lipids in exosome biology and intercellular communication: Function, analytics and applications.
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DOI：
10.1111/tra.12803
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发表时间：
2021-07
期刊：
影响因子：
--
通讯作者：
González-Valdez J
中科院分区：
文献类型：
--
作者：
Donoso-Quezada J;Ayala-Mar S;González-Valdez J
外来体是近年来因其在许多生物过程中的调节功能而受到特别关注的细胞外囊泡。最近的证据表明，体液中外来体的组成与某些疾病（如癌症、糖尿病和神经退行性疾病）的进展之间存在相关性。因此，已经进行了许多研究来评估这些囊泡的组成，旨在开发用于诊断的新生物标志物并找到新的治疗靶点。就其本身而言，脂质代表外泌体最重要的组分之一，在外泌体生物发生、释放、靶向和细胞摄取期间具有重要的结构和调节功能。因此，外泌体脂质组学已成为发现具有生物医学应用的新型脂质物种的创新学科。本文综述了外来体脂质及其在外来体生物学和细胞间通讯中的作用。此外，它还介绍了外泌体脂质组学中使用的最先进的分析方法，同时强调这一新兴学科如何为外泌体脂质在生物医学中的未来应用提供新的见解。外来体由于其在细胞间通讯中的关键作用而受到关注。因此，已经进行了几项详尽的工作来描述主要的外泌体组分（例如，miRNA、蛋白质和肽类脂质）及其调控功能。然而，尽管在这一领域取得了重要进展，外泌体脂质的研究才刚刚起步，目前对其调控功能的了解有限。本文介绍了外来体脂质的最新进展，强调它们在疾病进展中的作用和未来在生物医学中的应用。
Exosomes are extracellular vesicles that in recent years have received special attention for their regulatory functions in numerous biological processes. Recent evidence suggests a correlation between the composition of exosomes in body fluids and the progression of some disorders, such as cancer, diabetes and neurodegenerative diseases. In consequence, numerous studies have been performed to evaluate the composition of these vesicles, aiming to develop new biomarkers for diagnosis and to find novel therapeutic targets. On their part, lipids represent one of the most important components of exosomes, with important structural and regulatory functions during exosome biogenesis, release, targeting and cellular uptake. Therefore, exosome lipidomics has emerged as an innovative discipline for the discovery of novel lipid species with biomedical applications. This review summarizes the current knowledge about exosome lipids and their roles in exosome biology and intercellular communication. Furthermore, it presents the state‐of‐the‐art analytical procedures used in exosome lipidomics while emphasizing how this emerging discipline is providing new insights for future applications of exosome lipids in biomedicine. Exosomes have gained attention due to their pivotal role in intercellular communication. Therefore, several exhaustive works have been performed to describe the main exosomal components (e.g., miRNA, proteins and peptides lipids) and their regulatory functions. However, despite the important advances in this field, research in exosome lipids is incipient and the current understanding of their regulatory functions is limited. This review presents the most recent advances in exosome lipids emphasizing their role in disease progression and future applications in biomedicine.
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影响因子：
4.6
作者：
Buratta S;Shimanaka Y;Costanzi E;Ni S;Urbanelli L;Kono N;Morena F;Sagini K;Giovagnoli S;Romani R;Gargaro M;Arai H;Emiliani C
通讯作者：
Emiliani C
影响因子：
4
作者：
Colombo, Marina;Moita, Catarina;Raposo, Graca
通讯作者：
Raposo, Graca
DOI：
10.1152/ajpcell.1997.272.4.c1279
发表时间：
1997-04-01
影响因子：
5.5
作者：
Blackwood, RA;Smolen, JE;French, S
通讯作者：
French, S
DOI：
10.1016/b978-0-12-816053-4.00006-7
发表时间：
2020-01-01
期刊：
EXOSOMES: A CLINICAL COMPENDIUM
影响因子：
--
作者：
Cheng, Yong;Schorey, Jeffery S.
通讯作者：
Schorey, Jeffery S.
影响因子：
64.5
作者：
Crewe C;Joffin N;Rutkowski JM;Kim M;Zhang F;Towler DA;Gordillo R;Scherer PE
通讯作者：
Scherer PE