Systems biology: personalized medicine for the future?

Systems biology: personalized medicine for the future?
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DOI:
10.1016/j.coph.2012.07.011
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发表时间:
2012-10
影响因子:
4
通讯作者:
Snyder, Michael
Snyder, Michael
中科院分区:
医学3区
文献类型:
--
作者:
Chen, Rui;Snyder, Michael

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系统生物学正在积极地将现代医疗保健领域从基于生物学的疾病诊断和治疗转变为基于患者个体特征进行治疗的精准医学。高通量测序和质谱等高通量技术的发展使科学家和临床医生能够以前所未有的细节检查基因组、转录组、蛋白质组、代谢组和其他组学信息。这种“组学”信息导致全球健康和疾病概况,并为个性化健康监测和预防医学提供新的方法。本文回顾了系统生物学在个体化医疗领域近两年来的研究进展,详细讨论了系统生物学在个体化医疗领域取得的成就和存在的问题,以及未来个体化医疗的亮点和障碍。
Systems biology is actively transforming the field of modern health care from symptom-based disease diagnosis and treatment to precision medicine in which patients are treated based on their individual characteristics. Development of high-throughput technologies such as high-throughout sequencing and mass spectrometry has enabled scientists and clinicians to examine genomes, transcriptomes, proteomes, metabolomes, and other omics information in unprecedented detail. This “omics” information leads to a global profiling of health and disease, and providing new approaches for personalized health monitoring and preventative medicine. In this article, we review the efforts of systems biology in personalized medicine in the past 2 years, and discussed in detail achievements and concerns, as well as highlights and hurdles for future personalized health care.
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