Revisiting de Beer's textbook example of heterochrony and jaw elongation in fish: calmodulin expression reflects heterochronic growth, and underlies morphological innovation in the jaws of belonoid fishes.
Revisiting de Beer's textbook example of heterochrony and jaw elongation in fish: calmodulin expression reflects heterochronic growth, and underlies morphological innovation in the jaws of belonoid fishes.
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DOI：
10.1186/2041-9139-5-8
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发表时间：
2014-02-05
期刊：
影响因子：
4.1
通讯作者：
Meyer A
中科院分区：
文献类型：
--
作者：
Gunter HM;Koppermann C;Meyer A
个体发育过程中的异时性转变可能导致适应性的重要创新，并可能由简单的发展开关启动。了解这些发育事件的性质可以提供对进化变化的基本分子机制的见解。来自Belonoidei亚目的鱼类显示出大量的极端颅面形态，似乎是通过一系列的异时性变化而产生的。我们进行了分子heterochrony研究，比较胚后颌骨发育的Suborder Belonoidei的代表，半喙Dermogenys pusilla（其中下颌是相当长的上颌相比）和针鱼Belone belone（其中两个下巴都是细长的），他们的姐妹组的Suborder Adrianichthyoidei，青鳉Oryzias latipes，它保留了祖先的形态。在早期的发展，下颌显示加速增长，无论是在针鱼和halfbeak相比，青，和二次加速的上颌被认为是针鱼后来在他们的发展，代表的情况下马赛克heterochrony。我们确定了无齿的延伸作为创新的贝氏鱼类和异时生长的来源。通过比较半喙鱼和青鳉鱼发育过程中骨骼发生基因的表达，探讨了Belonoidei生长异时性的分子基础。钙调素paramycalm1被确定为一个潜在的调节器的下颌长度在半喙，因为它的表达逐渐增加，在下颌，但不是上颌，在一个模式，它的生长相匹配。此外，青鳉在上颌骨和下颌骨中显示出相同的calm1表达，这与该物种缺乏颌骨生长相一致。异时性的变化，在颌骨生长的过程中反复发生的贝氏鱼类的进化，我们确定无牙的延伸的牙齿作为一个重要的创新，这组。我们的研究结果表明，calm1有助于下巴异时性在halfbeak，可能会推动进一步异时性的转变，在整个Suborder Belonoidei的颌骨生长，如在针鱼中观察到的上颌加速度。
Heterochronic shifts during ontogeny can result in adaptively important innovations and might be initiated by simple developmental switches. Understanding the nature of these developmental events can provide insights into fundamental molecular mechanisms of evolutionary change. Fishes from the Suborder Belonoidei display a vast array of extreme craniofacial morphologies that appear to have arisen through a series of heterochronic shifts. We performed a molecular heterochrony study, comparing postembryonic jaw development in representatives of the Suborder Belonoidei, the halfbeak Dermogenys pusilla (where the lower jaw is considerably elongated compared to the upper jaw) and the needlefish Belone belone (where both jaws are elongated), to a representative of their sister group the Suborder Adrianichthyoidei, the medaka Oryzias latipes, which has retained the ancestral morphology. Early in development, the lower jaw displays accelerated growth both in needlefish and halfbeak compared to medaka, and secondary acceleration of the upper jaw is seen in needlefish later in their development, representing a case of mosaic heterochrony. We identified toothless extensions of the dentaries as innovations of Belonoid fishes and the source of heterochronic growth. The molecular basis of growth heterochronies in the Belonoidei was examined through comparing expression of skeletogenic genes during development of halfbeak and medaka. The calmodulin paralogue calm1 was identified as a potential regulator of jaw length in halfbeak as its expression gradually increases in the lower jaw, but not the upper jaw, in a pattern that matches its outgrowth. Moreover, medaka displays equal expression of calm1 in the upper and lower jaws, consistent with the lack of jaw outgrowth in this species. Heterochronic shifts in jaw growth have occurred repeatedly during the evolution of Belonoid fishes and we identify toothless extensions of the dentaries as an important innovation of this group. Our results suggest that calm1 contributes to jaw heterochrony in halfbeak, potentially driving further heterochronic shifts in jaw growth across the Suborder Belonoidei, such as the upper jaw acceleration observed in needlefish.
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影响因子：
2.7
作者：
ALBERCH, P;GOULD, SJ;WAKE, DB
通讯作者：
WAKE, DB
影响因子：
3.4
作者：
Albertson RC;Yan YL;Titus TA;Pisano E;Vacchi M;Yelick PC;Detrich HW 3rd;Postlethwait JH
通讯作者：
Postlethwait JH
影响因子：
2.2
作者：
Clemen, G;Wanninger, AC;Greven, H
通讯作者：
Greven, H
影响因子：
2.9
作者：
Gould, SJ
通讯作者：
Gould, SJ
影响因子：
2.2
作者：
Greven, H;Wanninger, AC;Clemen, G
通讯作者：
Clemen, G