Vitamin D status and antibody levels to common viruses in pediatric-onset multiple sclerosis.
Vitamin D status and antibody levels to common viruses in pediatric-onset multiple sclerosis.
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DOI：
10.1177/1352458510394398
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发表时间：
2011-06
期刊：
影响因子：
--
通讯作者：
Waubant E
中科院分区：
文献类型：
--
作者：
Mowry EM;James JA;Krupp LB;Waubant E
多发性硬化（MS）危险因素的相对贡献和相互作用尚未得到评估。确定维生素D状态是否与儿科发病MS或临床孤立综合征（CIS）患者和对照组中常见病毒的抗体水平相关。我们评估了维生素D状态是否与EB病毒、巨细胞病毒（CMV）和单纯疱疹病毒（HSV）-1或-2的病毒抗体水平相关，以及这些相关性是否因疾病状态而异。在140名受试者中，维生素D状态与CMV抗体水平弱相关，但与其他病毒无关。然而，维生素D状态和疾病状态之间存在一些相互作用。在维生素D充足（≥ 30 ng/mL）的患者中，MS/CIS患者的EB核抗原-1抗体水平高于对照组。维生素D充足与MS/CIS受试者中较高的CMV抗体水平相关，但与对照组中较低的CMV抗体水平相关。在MS/CIS患者中，较高的维生素D水平似乎与较高的HSV-2滴度相关，但与对照组无关。维生素D状态可能与血清阳性受试者中常见儿童病毒的抗体水平差异相关。
The relative contribution and interaction of risk factors for multiple sclerosis (MS) have not been evaluated. To determine if vitamin D status is associated with antibody levels to common viruses in pediatric-onset MS or clinically isolated syndrome (CIS) patients and controls. We assessed if vitamin D status was associated with viral antibody levels to Epstein-Barr virus, cytomegalovirus (CMV), and herpes simplex virus(HSV) -1 or -2 in subjects who demonstrated evidence of remote infection with these viruses and whether these associations differed depending on disease status. In 140 subjects, vitamin D status was weakly associated with antibody levels to CMV but not to the other viruses. However, there were some interactions between vitamin D status and disease state. Among those with vitamin D sufficiency (≥ 30 ng/mL), MS/CIS patients had higher antibody levels to Epstein-Barr nuclear antigen-1 than controls. Vitamin D sufficiency was associated with higher CMV antibody levels in MS/CIS subjects but lower CMV antibody levels in controls. Higher vitamin D levels appeared to be associated with higher titers to HSV-2 in MS/CIS patients but not controls. Vitamin D status may be differentially associated with antibody levels to common childhood viruses among seropositive subjects.
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影响因子：
3.7
作者：
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通讯作者：
Fawzi WW
影响因子：
11.2
作者：
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通讯作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
5
作者：
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通讯作者：
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