Fundamentals and applications of nanoparticles for ultrasound‐based imaging and therapy

Fundamentals and applications of nanoparticles for ultrasound‐based imaging and therapy
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用于超声成像和治疗的纳米颗粒的基础知识和应用

DOI:
10.1002/nano.202000035
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发表时间:
2020-09
期刊:
Nano Select
影响因子:
--
通讯作者:
Jun Pang
Jun Pang
中科院分区:
其他
文献类型:
--
作者:
Lujing Li;Yupeng Guan;Haiyun Xiong;Tian Deng;Qiao Ji;Zuofeng Xu;Yang Kang;Jun Pang

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超声检查由于其固有的优点而被广泛应用于临床影像学。基于纳米颗粒(NP)的成像和治疗方式由于其独特的功能和高性能而被广泛应用。本文主要介绍NPs的分类及其在美国治疗性生物医学中的应用。基于美国的应用包括单模态超声成像、多模态超声成像、高强度聚焦超声成像、超声触发药物释放、超声增强基因转染和超声辐射声动力治疗。此外,目前的挑战,包括生物效应和生物安全,在这次采访中进行了讨论。NPs作为一种基于美国的治疗工具具有巨大的潜力,并揭示了癌症治疗的新方向。
Ultrasonography (US) is frequently applied in clinical imaging because of its inherent merits compared with those of other imaging methods. Nanoparticle (NP)‐based imaging and therapeutic modalities have been widely used because of their unique functionalities and high performance. The report is mainly about the classifications and applications of NPs for US‐based theranostic biomedicine. The US‐based applications include single‐modality US imaging, multimodality US imaging, high‐intensity focused US, US‐triggered drug release, US‐enhanced gene transfection, and US‐irradiated sonodynamic therapy. In addition, current challenges, including the biological effects and biosafety, are discussed in this interview. NPs have tremendous potential as a US‐based theranostic tool and have revealed a new direction in cancer therapy.
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