Theranostic USPIO-Loaded Microbubbles for Mediating and Monitoring Blood-Brain Barrier Permeation.
Theranostic USPIO-Loaded Microbubbles for Mediating and Monitoring Blood-Brain Barrier Permeation.
复制标题
DOI：
10.1002/adfm.201401199
复制
发表时间：
2015-01-07
影响因子：
19
通讯作者：
Kiessling, Fabian
中科院分区：
文献类型：
--
作者：
Lammers, Twan;Koczera, Patrick;Fokong, Stanley;Gremse, Felix;Ehling, Josef;Vogt, Michael;Pich, Andrij;Storm, Gert;van Zandvoort, Marc;Kiessling, Fabian
如何安全有效地通过血脑屏障给药是生物医学和纳米制药研究的主要挑战之一。在这里，我们表明，聚（氰基丙烯酸丁酯）为基础的微泡（MB），携带超小超顺磁性氧化铁（USPIO）纳米粒子在其壳内，可用于调解和监测血脑屏障渗透。暴露于经颅超声脉冲后，USPIO-MB被破坏，导致声力诱导血管通透性。同时，USPIO从MB壳中释放，它们外渗穿过透化的BBB，并在血管外脑组织中积累，从而提供关于BBB开放程度的基于R2* 的非侵入性磁共振成像信息。R2* 弛豫测定的定量变化与大分子模型药物FITC-葡聚糖血管外沉积到脑中的2D和3D显微镜结果非常一致。这样的治疗诊断材料和方法被认为可用于介导和监测穿过BBB的药物递送，并且可用于实现CNS病症的安全和有效治疗。
Efficient and safe drug delivery across the blood-brain barrier (BBB) remains to be one of the major challenges of biomedical and (nano-) pharmaceutical research. Here, we show that poly(butyl cyanoacrylate)-based microbubbles (MB), carrying ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles within their shell, can be used to mediate and monitor BBB permeation. Upon exposure to transcranial ultrasound pulses, USPIO-MB are destroyed, resulting in acoustic forces inducing vessel permeability. At the same time, USPIO are released from the MB shell, they extravasate across the permeabilized BBB and they accumulate in extravascular brain tissue, thereby providing non-invasive R2*-based magnetic resonance imaging information on the extent of BBB opening. Quantitative changes in R2* relaxometry were in good agreement with 2D and 3D microscopy results on the extravascular deposition of the macromolecular model drug FITC-dextran into the brain. Such theranostic materials and methods are considered to be useful for mediating and monitoring drug delivery across the BBB, and for enabling safe and efficient treatment of CNS disorders.
登录
查看更多内容
DOI：
10.1016/j.jconrel.2012.09.007
发表时间：
2012-11-10
期刊：
Journal of controlled release : official journal of the Controlled Release Society
影响因子：
--
作者：
Park EJ;Zhang YZ;Vykhodtseva N;McDannold N
通讯作者：
McDannold N
影响因子：
2.9
作者：
Brown, RC;Egleton, RD;Davis, TP
通讯作者：
Davis, TP
DOI：
10.1073/pnas.1105116108
发表时间：
2011-10-04
影响因子：
11.1
作者：
Choi, James J.;Selert, Kirsten;Konofagou, Elisa E.
通讯作者：
Konofagou, Elisa E.
影响因子：
14
作者：
Jayapaul, Jabadurai;Hodenius, Michael;Gaetjens, Jessica
通讯作者：
Gaetjens, Jessica
影响因子：
5.7
作者：
Hynynen, K;McDannold, N;Vykhodtseva, N
通讯作者：
Vykhodtseva, N