CCR7 ligands stimulate the intranodal motility of T lymphocytes in vivo.
CCR7 ligands stimulate the intranodal motility of T lymphocytes in vivo.
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CCR7配体刺激体内T淋巴细胞的鼻内运动性。
DOI：
10.1084/jem.20061706
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发表时间：
2007-03-19
影响因子：
15.3
通讯作者：
Foerster, Reinhold
中科院分区：
文献类型：
--
作者：
Worbs, Tim;Mempel, Thorsten R.;Boelter, Jasmin;von Andrian, Ulrich H.;Foerster, Reinhold
In contrast to lymphocyte homing, little is known about molecular cues controlling the motility of lymphocytes within lymphoid organs. Applying intravital two-photon microscopy, we demonstrate that chemokine receptor CCR7 signaling enhances the intranodal motility of CD4+ T cells. Compared to wild-type (WT) cells, the average velocity and mean motility coefficient of adoptively transferred CCR7-deficient CD4+ T lymphocytes in T cell areas of WT recipients were reduced by 33 and 55%, respectively. Both parameters were comparably reduced for WT T lymphocytes migrating in T cell areas of plt/plt mice lacking CCR7 ligands. Importantly, systemic application of the CCR7 ligand CCL21 was sufficient to rescue the motility of WT T lymphocytes inside T cell areas of plt/plt recipients. Comparing the movement behavior of T cells in subcapsular areas that are devoid of detectable amounts of CCR7 ligands even in WT mice, we failed to reveal any differences between WT and plt/plt recipients. Furthermore, in both WT and plt/plt recipients, highly motile T cells rapidly accumulated in the subcapsular region after subcutaneous injection of the CCR7 ligand CCL19. Collectively, these data identify CCR7 and its ligands as important chemokinetic factors stimulating the basal motility of CD4+ T cells inside lymph nodes in vivo.
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影响因子：
9.8
作者：
Witt, CM;Raychaudhuri, S;Robey, EA
通讯作者：
Robey, EA
DOI：
10.1073/pnas.2628040100
发表时间：
2003-03-04
影响因子：
11.1
作者：
Miller, MJ;Wei, SH;Parker, I
通讯作者：
Parker, I
DOI：
10.1073/pnas.97.23.12694
发表时间：
2000-11-07
影响因子：
11.1
作者：
Luther, SA;Tang, HL;Cyster, JG
通讯作者：
Cyster, JG
影响因子：
9.8
作者：
Okada T;Miller MJ;Parker I;Krummel MF;Neighbors M;Hartley SB;O'Garra A;Cahalan MD;Cyster JG
通讯作者：
Cyster JG
影响因子：
64.5
作者：
Förster, R;Schubel, A;Lipp, M
通讯作者：
Lipp, M