Memory-based mismatch response to changes in duration of auditory stimuli: An MEG study
Memory-based mismatch response to changes in duration of auditory stimuli: An MEG study
复制标题
基于记忆的对听觉刺激持续时间变化的不匹配反应：脑磁图研究
DOI：
10.1016/j.clinph.2010.04.003
复制
发表时间：
2010
影响因子：
4.7
通讯作者：
Yung
中科院分区：
文献类型：
--
作者：
Wan;Chia;Hsuan;K. Liao;Zin;L. Ho;Yung
目的在古怪范式中，标准和偏差在物理特征和发生概率上的差异对磁失配负性(MMNm)有贡献。我们的目的是减少这些影响因素，并通过增加一个对照范式来提取基于记忆的MMNm。方法记录了13名健康成年人的脑磁图反应，他们使用奇怪的范式(125ms标准音和50ms偏离音)和等概率控制范式(50ms控制音和其他4个时长变化的音调)。刺激起始不同步时间为500ms。控制MMNm是从异常诱发反应中减去控制诱发反应得到的。结果在刺激开始时间方面，控制MMNm的峰潜伏期与以往的颅内MMN记录一致。对照MMNm和传统MMNm均在颞叶上皮质周围产生，而控制MMNm波幅约为传统MMNm波幅的70%。传统MMNm存在右半球优势，而对照MMNm则未观察到右半球优势。标准诱发的N100M波幅小于异常或控制诱发的反应。结论控制性MMNm反映了对时长变化的基于记忆的加工，而传统的MMNm还涉及与标准刺激和异常刺激之间的不同不应状态和物理性质相关的非记忆激活。
OBJECTIVEDifferences in physical features and occurrence probability between standards and deviants in oddball paradigms provide contributions to magnetic mismatch negativity (MMNm). We aimed to reduce these influential factors and extract memory-based MMNm by adding a control paradigm.METHODSMagnetoencephalographic responses were recorded in 13 healthy adults with an oddball paradigm (125-ms standard and 50-ms deviant tones) and an equiprobable control paradigm (50-ms control and four other duration-varying tones). The stimulus onset asynchrony was 500ms. Controlled MMNm was obtained by subtracting control-evoked responses from deviant-evoked responses.RESULTSWith respect to the onset of stimulus difference, the peak latency of controlled MMNm was compatible with previous intracranial MMN recordings. Both controlled and traditional MMNm were generated around the superior temporal cortex, whereas the controlled MMNm amplitude was about 70% of traditional MMNm amplitude. Right-hemispheric dominance was observed in traditional MMNm but not in controlled MMNm. N100m amplitude was smaller in standard-evoked than in deviant- or control-evoked responses.CONCLUSIONSControlled MMNm reflects memory-based processing of duration changes, whereas traditional MMNm additionally involves non-memory activations related to differential refractoriness states and physical properties between standard and deviant stimuli.SIGNIFICANCEThe memory-based processing of auditory deviants may be preferentially extracted by adding a control paradigm.
DOI：
10.1016/s0168-5597(97)00057-9
发表时间：
1997-11-01
期刊：
EVOKED POTENTIALS-ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY
影响因子：
--
作者：
Alain, C;Woods, DL;Covarrubias, D
通讯作者：
Covarrubias, D
影响因子：
56.9
作者：
CASSEDAY, JH;EHRLICH, D;COVEY, E
通讯作者：
COVEY, E