Transgenerational impact of intimate partner violence on methylation in the promoter of the glucocorticoid receptor.
Transgenerational impact of intimate partner violence on methylation in the promoter of the glucocorticoid receptor.
复制标题
DOI：
10.1038/tp.2011.21
复制
发表时间：
2011-07-19
影响因子：
6.8
通讯作者：
Elbert T
中科院分区：
文献类型：
--
作者：
Radtke KM;Ruf M;Gunter HM;Dohrmann K;Schauer M;Meyer A;Elbert T
产前暴露于母体压力可能对心理功能产生终身影响，例如行为问题，甚至精神疾病的发展。先前的研究表明，这是由于下丘脑-垂体-肾上腺轴中基因的跨代表观遗传编程，如糖皮质激素受体（GR）。然而，目前尚不清楚宫内暴露于母体压力是否会影响这些基因在婴儿期后的表观遗传状态。在这里，我们分析了母亲及其子女在出生后10-19岁时GR基因的甲基化状态。我们将这些数据与母亲暴露于亲密伴侣暴力（IPV）的回顾性评价相结合。母亲的GR基因甲基化不受IPV的影响。我们首次发现，青春期儿童GR基因的甲基化状态受到母亲在怀孕期间IPV经历的影响。由于这些持续的表观遗传修饰是在子宫内建立的，我们认为这是一个合理的机制，产前压力可能程序成年人的心理社会功能。
Prenatal exposure to maternal stress can have lifelong implications for psychological function, such as behavioral problems and even the development of mental illness. Previous research suggests that this is due to transgenerational epigenetic programming of genes operating in the hypothalamic–pituitary–adrenal axis, such as the glucocorticoid receptor (GR). However, it is not known whether intrauterine exposure to maternal stress affects the epigenetic state of these genes beyond infancy. Here, we analyze the methylation status of the GR gene in mothers and their children, at 10–19 years after birth. We combine these data with a retrospective evaluation of maternal exposure to intimate partner violence (IPV). Methylation of the mother's GR gene was not affected by IPV. For the first time, we show that methylation status of the GR gene of adolescent children is influenced by their mother's experience of IPV during pregnancy. As these sustained epigenetic modifications are established in utero, we consider this to be a plausible mechanism by which prenatal stress may program adult psychosocial function.
登录
查看更多内容
影响因子：
1.1
作者：
Hegarty, Kelsey;Fracgp;Sheehan, Mary
通讯作者：
Sheehan, Mary
影响因子：
3.7
作者：
Oberlander, Tim F.;Weinberg, Joanne;Devlin, Angela M.
通讯作者：
Devlin, Angela M.
影响因子：
2.5
作者：
DOBBING, J;SANDS, J
通讯作者：
SANDS, J
影响因子：
10.6
作者：
O'Connor, TG;Ben-Shlomo, Y;Glover, V
通讯作者：
Glover, V
影响因子：
9.3
作者：
Gregory SG;Connelly JJ;Towers AJ;Johnson J;Biscocho D;Markunas CA;Lintas C;Abramson RK;Wright HH;Ellis P;Langford CF;Worley G;Delong GR;Murphy SK;Cuccaro ML;Persico A;Pericak-Vance MA
通讯作者：
Pericak-Vance MA