Daily Rhythms of TNFα Expression and Food Intake Regulate Synchrony of Plasmodium Stages with the Host Circadian Cycle.
Daily Rhythms of TNFα Expression and Food Intake Regulate Synchrony of Plasmodium Stages with the Host Circadian Cycle.
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TNFα表达和食物摄入的每日节奏调节质量阶段与宿主昼夜节律的同步。
DOI：
10.1016/j.chom.2018.04.016
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发表时间：
2018-06-13
影响因子：
30.3
通讯作者：
Gazzinelli RT
中科院分区：
文献类型：
--
作者：
Hirako IC;Assis PA;Hojo-Souza NS;Reed G;Nakaya H;Golenbock DT;Coimbra RS;Gazzinelli RT
疟原虫的细胞周期，其中数百万的寄生虫分化和增殖，发生同步与脊椎动物宿主的昼夜节律周期。其潜在机制尚不清楚。在这里，我们解决了这个问题，在小鼠模型的夏氏疟原虫感染。在来自夏氏疟原虫感染小鼠的IFNγ致敏的白细胞和肝细胞中，炎症基因表达和碳水化合物代谢均增强。TNFα表达在宿主昼夜节律周期中振荡，TNFα增加与低血糖和滋养体非复制性环状体频率较高相关。相反，寄生虫在宿主摄取食物期间增殖并获得生物量。重要的是，在IFNγ-/-、TNF受体-/-或糖尿病小鼠中，周期性低血糖被减弱，查氏疟原虫阶段的同步被破坏。因此，系统性TNFα产生和宿主食物摄入的每日节律设定了疟原虫与宿主昼夜周期同步的步伐。这种机制表明疟原虫寄生虫利用宿主的进食习惯。疟原虫感染的一个标志是周期性发热，随后是受感染红细胞的同步破裂。数以百万计的寄生虫是如何同步增殖的尚不清楚。Hirako等人发现，炎症诱导的低血糖会损害寄生虫的复制，而疟原虫在宿主进食期间增殖，这与宿主的昼夜节律周期平行。
The Plasmodium cell cycle, wherein millions of parasites differentiate and proliferate, occurs in synchrony with the vertebrate host’s circadian cycle. The underlying mechanisms are unknown. Here we addressed this question in a mouse model of Plasmodium chabaudi infection. Inflammatory gene expression and carbohydrate metabolism are both enhanced in IFNγ-primed leukocytes and liver cells from P. chabaudi-infected mice. TNFα expression oscillates across the host circadian cycle, and increased TNFα correlates with hypoglycemia and a higher frequency of non-replicative ring forms of trophozoites. Conversly, parasites proliferate and acquire biomass during food intake by the host. Importantly, cyclic hypoglycemia is attenuated and synchronization of P. chabaudi stages is disrupted in IFNγ−/−, TNF receptor−/− or diabetic mice. Hence, the daily rhythm of systemic TNFα production and host food intake set the pace for Plasmodium synchronization with host’s circadian cycle. This mechanism indicates that Plasmodium parasites take advantage of the host’s feeding habits. A hallmark of Plasmodium infection is a cyclic fever preceded by the synchronized rupture of infected erythrocytes. How millions of parasites proliferate synchronously is unknown. Hirako et al. found that inflammation-induced hypoglycemia impairs parasite replication, whereas Plasmodium proliferates during host food intake, which parallels the host’s circadian cycle.
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高温温度可以在体外同步恶性疟原虫的生长。
DOI：
10.1084/jem.169.1.357
发表时间：
1989-01-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Kwiatkowski D
通讯作者：
Kwiatkowski D
影响因子：
6.4
作者：
Gordon EB;Hart GT;Tran TM;Waisberg M;Akkaya M;Skinner J;Zinöcker S;Pena M;Yazew T;Qi CF;Miller LH;Pierce SK
通讯作者：
Pierce SK
影响因子：
16.6
作者：
Hirako, Isabella C.;Ataide, Marco A.;Faustino, Lucas;Assis, Patricia A.;Sorensen, Elizabeth W.;Ueta, Hisashi;Araujo, Natalia M.;Menezes, Gustavo B.;Luster, Andrew D.;Gazzinelli, Ricardo T.
通讯作者：
Gazzinelli, Ricardo T.
影响因子：
4.4
作者：
Bartholomeu, Daniella C.;Ropert, Catherine;Gazzinelli, Ricardo T.
通讯作者：
Gazzinelli, Ricardo T.
影响因子：
7.7
作者：
Emanueli, C;Graiani, G;Madeddu, P
通讯作者：
Madeddu, P