Infection and Stroke: an Update on Recent Progress.

Infection and Stroke: an Update on Recent Progress.
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DOI:
10.1007/s11910-015-0602-9
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发表时间:
2016-01
影响因子:
5.6
通讯作者:
Elkind MS
Elkind MS
中科院分区:
医学2区
文献类型:
--
作者:
Miller EC;Elkind MS

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感染在脑血管疾病中的作用是复杂的,目前仍不完全清楚。在过去的5年里,调查人员在解决这个棘手的问题上取得了显著的进展。在这篇综述中,我们考察了这些最新的发展,集中在感染和中风之间关系的四个方面。我们首先讨论作为中风的直接原因的特定感染源,集中在最近关于疱疹病毒和艾滋病毒与脑血管疾病有关的工作。然后,我们讨论任何类型的系统性感染作为中风的触发因素,重点是感染与急性中风的时间的关系,无论是在儿童还是成人,以及接种疫苗在中风预防中的作用。我们研究了慢性感染或“感染负担”作为中风风险因素的证据。最后,我们讨论了最近关于感染作为卒中后发病率增加的危险因素的工作,可能的机制,以及预防性抗生素的证据。
The role of infection in cerebrovascular disease is complex and remains incompletely understood. Over the last 5 years, investigators have made notable inroads in untangling this thorny topic. In this review, we examine these recent developments, concentrating on four aspects of the relationship between infection and stroke. We first discuss specific infectious agents as direct causes of stroke, focusing on recent work implicating herpesviruses and HIV in cerebral vasculopathy. We then discuss systemic infection of any type as a stroke trigger, focusing on the relationship of infection to timing of acute stroke, both in children and adults, as well as the role of vaccination in stroke prevention. We examine the evidence for chronic infection or “infectious burden” as a stroke risk factor. Finally, we discuss recent work on infection as a risk factor for increased morbidity after stroke, possible mechanisms mediating this effect, and the evidence for prophylactic antibiotics.
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