Self-assembled nanoscale coordination polymers with trigger release properties for effective anticancer therapy.
Self-assembled nanoscale coordination polymers with trigger release properties for effective anticancer therapy.
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DOI：
10.1038/ncomms5182
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发表时间：
2014-06-25
影响因子：
16.6
通讯作者：
Lin, Wenbin
中科院分区：
文献类型：
--
作者：
Liu, Demin;Poon, Christopher;Lu, Kuangda;He, Chunbai;Lin, Wenbin
纳米配位聚合物（NCPs）是由金属离子和有机桥接配体自组装而成的，并且可以克服现有药物递送系统的许多缺点，其凭借可调节的组成、尺寸和形状;高药物载量;易于表面修饰;以及固有的生物降解性。在这里，我们报告了携带48±3重量%顺铂前药和45±5重量%奥沙利铂前药的二膦酸锌NCP的自组装。小鼠体内药代动力学研究显示，单核吞噬细胞系统对聚乙二醇化NCP的摄取最小，携带顺铂和奥沙利铂的NCP的血液循环半衰期分别为16.4±2.9和12.0±3.9 h。在评价的所有肿瘤异种移植模型中，包括CT 26结肠癌、H460肺癌和AsPC-1胰腺癌，与游离药物相比，聚乙二醇化NCP显示出上级效力和功效。作为使用NCP作为具有增强的抗肿瘤活性的纳米治疗剂的第一个例子，本研究将NCP确立为用于癌症治疗的有前途的药物递送平台。
Nanoscale coordination polymers (NCPs) are self-assembled from metal ions and organic bridging ligands, and can overcome many drawbacks of existing drug delivery systems by virtue of tunable compositions, sizes, and shapes; high drug loadings; ease of surface modification; and intrinsic biodegradability. Here we report the self-assembly of zinc bisphosphonate NCPs that carry 48±3 wt% cisplatin prodrug and 45±5 wt% oxaliplatin prodrug. In vivo pharmacokinetic studies in mice show minimal uptake of pegylated NCPs by the mononuclear phagocyte system and excellent blood circulation half-lives of 16.4±2.9 and 12.0±3.9 h for the NCPs carrying cisplatin and oxaliplatin, respectively. In all tumor xenograft models evaluated, including CT26 colon cancer, H460 lung cancer, and AsPC-1 pancreatic cancer, pegylated NCPs show superior potency and efficacy compared to free drugs. As the first example of using NCPs as nanotherapeutics with enhanced antitumor activities, this study establishes NCPs as a promising drug delivery platform for cancer therapy.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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作者：
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通讯作者：
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DOI：
10.1073/pnas.1011379108
发表时间：
2011-02-01
影响因子：
11.1
作者：
Dhar, Shanta;Kolishetti, Nagesh;Farokhzad, Omid C.
通讯作者：
Farokhzad, Omid C.