Polymeric micelles for the delivery of poorly soluble drugs: From nanoformulation to clinical approval.
Polymeric micelles for the delivery of poorly soluble drugs: From nanoformulation to clinical approval.
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DOI：
10.1016/j.addr.2020.09.009
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发表时间：
2020
影响因子：
16.1
通讯作者：
Kabanov AV
中科院分区：
文献类型：
--
作者：
Hwang D;Ramsey JD;Kabanov AV
在过去的三十年里，聚合物胶束已经成为一个非常有前途的药物输送平台的治疗化合物。特别地，具有高效力和显著毒性的难溶性小分子被封装在聚合物胶束中。聚合物胶束在临床前动物模型中显示出改善的药代动力学特征，并且对于治疗药物具有增强的功效和优异的上级安全性特征。几种聚合物胶束制剂已经达到临床阶段，并且处于临床试验中或被批准用于人类使用。这进一步促进了对该领域的兴趣，并强调了需要额外学习如何最好地设计和应用这些胶束载体来改善许多药物的临床结果。在这篇综述中，我们提供了详细的信息聚合物胶束溶解的难溶性小分子的主题，如嵌段共聚物的设计，药物封装在聚合物胶束的实验和理论分析，药物在聚合物胶束的药代动力学，监管批准途径的纳米药物，和目前的结果胶束制剂在临床试验。我们的目的是描述先进的分析方法，阐明有效的增溶聚合物胶束的核心内的分子相互作用，以及分析纳米药物的药代动力学概况的最新信息。考虑到本文所述的考虑因素，学术和工业研究人员可以继续阐明聚合物胶束中的新型相互作用，并利用其作为药物递送载体的潜力，以帮助改善全身递送的治疗效果。
Over the last three decades, polymeric micelles have emerged as a highly promising drug delivery platform for therapeutic compounds. Particularly, poorly soluble small molecules with high potency and significant toxicity were encapsulated in polymeric micelles. Polymeric micelles have shown improved pharmacokinetic profiles in preclinical animal models and enhanced efficacy with a superior safety profile for therapeutic drugs. Several polymeric micelle formulations have reached the clinical stage and are either in clinical trials or are approved for human use. This furthers interest in this field and underscores the need for additional learning of how to best design and apply these micellar carriers to improve the clinical outcomes of many drugs. In this review, we provide detailed information on polymeric micelles for the solubilization of poorly soluble small molecules in topics such as the design of block copolymers, experimental and theoretical analysis of drug encapsulation in polymeric micelles, pharmacokinetics of drugs in polymeric micelles, regulatory approval pathways of nanomedicines, and current outcomes from micelle formulations in clinical trials. We aim to describe the latest information on advanced analytical approaches for elucidating molecular interactions within the core of polymeric micelles for effective solubilization as well as for analyzing nanomedicine’s pharmacokinetic profiles. Taking into account the considerations described within, academic and industrial researchers can continue to elucidate novel interactions in polymeric micelles and capitalize on their potential as drug delivery vehicles to help improve therapeutic outcomes in systemic delivery.
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影响因子：
6
作者：
Bludau H;Czapar AE;Pitek AS;Shukla S;Jordan R;Steinmetz NF
通讯作者：
Steinmetz NF
影响因子：
6
作者：
Babu, RJ;Pandit, JK
通讯作者：
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影响因子：
5.5
作者：
Akiyama, Y;Harada, A;Kataoka, K
通讯作者：
Kataoka, K
DOI：
10.5539/jmbr.v8n1p1
发表时间：
2018-01-01
期刊：
JOURNAL OF MOLECULAR BIOLOGY RESEARCH
影响因子：
--
作者：
Behnaz, Faranak;Ghasemi, Mahshid;Shabanpour, Yalda
通讯作者：
Shabanpour, Yalda
影响因子：
4.9
作者：
Alakhova DY;Kabanov AV
通讯作者：
Kabanov AV