Cholecystectomy versus central obesity or insulin resistance in relation to the risk of nonalcoholic fatty liver disease: the third US National Health and Nutrition Examination Survey
Cholecystectomy versus central obesity or insulin resistance in relation to the risk of nonalcoholic fatty liver disease: the third US National Health and Nutrition Examination Survey
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胆囊切除术与中心性肥胖或胰岛素抵抗与非酒精性脂肪肝疾病风险的关系：第三次美国国家健康和营养检查调查
DOI：
10.1186/s12902-019-0423-y
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发表时间：
2019-09
影响因子：
2.7
通讯作者：
Du Tingting
中科院分区：
文献类型：
--
作者：
Yue Wenzhu;Sun Xingxing;Du Tingting
背景胆囊切除术、向心性肥胖和胰岛素抵抗（IR）是非酒精性脂肪性肝病（NAFLD）的既定危险因素。我们的目的是研究胆囊切除术和向心性肥胖/IR 与 NAFLD 风险的相对贡献和综合关联。方法我们对第三次全国健康和营养检查调查 (NHANES III) 的数据进行了横断面分析，其中进行了超声检查。使用逻辑回归估计 NAFLD 的比值比 (OR) 和 95% 置信区间。结果在中心性肥胖和非中心性肥胖受试者中，与胆囊结石相比，胆囊切除术与 NAFLD 的患病率较高相关。仅在存在中心性肥胖的情况下，胆结石与 NAFLD 患病率较高相关。在中心性肥胖参与者中，OR 从没有胆结石疾病的参与者的 2.67 (2.15–3.32) 增加到接受胆囊切除术的参与者的 6.73 (4.40–10.29)。在接受胆囊切除术的参与者中，OR 从无中心性肥胖参与者的 2.57 (1.35–4.89) 增加到中心性肥胖参与者的 6.73 (4.40–10.29)。我们观察到，与 IR 或代谢综合征的风险大幅增加相比，胆囊切除术导致 NAFLD 的风险略有增加。结论 在综合分析中，胆囊切除术造成的 NAFLD 风险程度与向心性肥胖相似。与 IR 或代谢综合征的关联程度大于与胆囊切除术的关联程度。
BackgroundCholecystectomy, central obesity, and insulin resistance (IR) are established risk factors for nonalcoholic fatty liver disease (NAFLD). We aimed to examine the relative contributions and combined association of cholecystectomy and central obesity/IR with NAFLD risk.MethodsWe conducted a cross-sectional analysis of data from the third National Health and Nutrition Examination Survey (NHANES III), in which ultrasonography was performed. Odds ratios (ORs) and 95% confidence intervals for NAFLD were estimated using logistic regression.ResultsCholecystectomy associated with a higher prevalence of NAFLD compared with gallstones among both centrally obese and non-centrally-obese subjects. Gallstones associated with a higher prevalence of NAFLD only in the presence of central obesity. In centrally obese participants, the OR increased from 2.67 (2.15–3.32) for participants without gallstone disease to 6.73 (4.40–10.29) for participants with cholecystectomy. In participants with cholecystectomy, the OR increased from 2.57 (1.35–4.89) for participants without central obesity to 6.73 (4.40–10.29) for centrally obese counterparts. We observed a modest increase in the risk of NAFLD with cholecystectomy compared with a large increase in the risk with IR or metabolic syndrome.ConclusionThe magnitude of the NAFLD risk contributed by cholecystectomy was similar to central obesity in combined analyses. The magnitude of the association with IR or metabolic syndrome was greater than with cholecystectomy.
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影响因子：
5.3
作者：
通讯作者：
--
影响因子：
9.8
作者：
Ruhl, Constance E.;Everhart, James E.
通讯作者：
Everhart, James E.
DOI：
10.1136/bmj.d6891
发表时间：
2011-11-18
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Lazo M;Hernaez R;Bonekamp S;Kamel IR;Brancati FL;Guallar E;Clark JM
通讯作者：
Clark JM
影响因子：
13.5
作者：
D. Q. Wang;S. Lee
通讯作者：
D. Q. Wang;S. Lee
影响因子：
15.9
作者：
Donnelly, KL;Smith, CI;Parks, EJ
通讯作者：
Parks, EJ