Fetal-placental antigens and the maternal immune system: Reproductive immunology comes of age.
Fetal-placental antigens and the maternal immune system: Reproductive immunology comes of age.
复制标题
胎儿植物抗原和母体免疫系统：生殖免疫学成年。
DOI：
10.1111/imr.13090
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发表时间：
2022-07
影响因子：
8.7
通讯作者：
中科院分区：
文献类型：
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作者：
生殖生理学和免疫学作为科学学科，各自都有丰富的、基本上独立的历史。古希腊的内科医生和哲学家对再生、疾病和免疫作出了非凡的观察和推论。文艺复兴时期的科学启蒙和上个世纪的技术进步导致了我们今天所经历的知识爆炸。移植、免疫学和生殖方面的突破最终以梅达瓦尔发现获得性免疫耐受而达到顶峰，这有助于解释移植的成功和失败。梅达瓦的思考也敏锐地指出，胎儿显然打破了这些新发现的规则，于是生殖免疫学领域就这样启动了。由于源于移植免疫学，科学家仍然将胎儿比作成功的同种异体移植。尽管我们现在知道了两者之间的根本区别，但这个类比仍然是一个有用的工具，可以理解胎儿是如何发育的，尽管它与母亲的免疫系统存在差异。在这里，我们回顾了生殖免疫学的历史，以及来自胎儿和移植器官的主要和次要组织相容抗原、血型抗原和组织特异性自身抗原是如何平行和不同的。
Reproductive physiology and immunology as scientific disciplines each have rich, largely independent histories. The physicians and philosophers of ancient Greece made remarkable observations and inferences to explain regeneration as well as illness and immunity. The scientific enlightenment of the renaissance and the technological advances of the past century have led to the explosion of knowledge that we are experiencing today. Breakthroughs in transplantation, immunology, and reproduction eventually culminated with Medawar’s discovery of acquired immunological tolerance, which helped to explain the transplantation success and failure. Medawar’s musings also keenly pointed out that the fetus apparently breaks these newly discovered rules, and with this, the field of reproductive immunology was launched. As a result of having stemmed from transplantation immunology, scientist still analogizes the fetus to a successful allograft. Although we now know of the fundamental differences between the two, this analogy remains a useful tool to understand how the fetus thrives despite its immunological disparity with the mother. Here, we review the history of reproductive immunology, and how major and minor histocompatibility antigens, blood group antigens, and tissue‐specific “self” antigens from the fetus and transplanted organs parallel and differ.
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DOI：
10.1111/j.1600-0897.2004.00156.x
发表时间：
2004-04-01
影响因子：
3.6
作者：
Abrahams, VM;Kim, YM;Mor, G
通讯作者：
Mor, G
DOI：
10.4049/jimmunol.0802454
发表时间：
2009-05-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Choi JC;Holtz R;Murphy SP
通讯作者：
Murphy SP
影响因子：
3.6
作者：
Aït-Azzouzene, D;Caucheteux, S;Kanellopoulos-Langevin, C
通讯作者：
Kanellopoulos-Langevin, C
影响因子：
30.5
作者：
Aschenbrenner, Katharina;D'Cruz, Louise M.;Klein, Ludger
通讯作者：
Klein, Ludger
影响因子：
15.3
作者：
Cai, JC;Lee, J;Burlingham, WJ
通讯作者：
Burlingham, WJ