Management of cytoskeleton architecture by molecular chaperones and immunophilins.
Management of cytoskeleton architecture by molecular chaperones and immunophilins.
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DOI：
10.1016/j.cellsig.2011.07.023
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发表时间：
2011-12
影响因子：
4.8
通讯作者：
Galigniana MD
中科院分区：
文献类型：
--
作者：
Quintá HR;Galigniana NM;Erlejman AG;Lagadari M;Piwien-Pilipuk G;Galigniana MD
细胞骨架结构不断重塑，以适应正常的细胞生长和响应病理生理线索。因此，几种细胞因子相互作用蛋白参与多种细胞过程，如细胞生长和分裂、细胞运动、囊泡运输、细胞器定位和功能、膜受体的定位和分布以及细胞-细胞通讯。分子伴侣和亲免蛋白是与细胞骨架网络密切相互作用的最重要的蛋白质，特别是与微管和微管相关因子。在一些情况下，热休克蛋白和亲免素作为功能活性的异源复合物一起工作，尽管这两种类型的蛋白质也显示出独立的作用。在稳态受到环境压力或遗传改变影响的情况下，伴侣蛋白有助于稳定系统。分子伴侣促进细胞骨架蛋白的组装、拆卸和/或折叠/重折叠，因此它们防止异常蛋白质聚集。尽管如此，热休克蛋白和免疫亲素的作用不仅限于解决异常情况，而且它们还积极参与细胞的正常分化过程，并且是该过程中许多结构和功能重排的关键因素。细胞骨架修饰导致核因子的定位改变，可能导致这些因子的功能丧失或获得，从而影响细胞周期和细胞发育。因此，细胞骨架成分是有吸引力的治疗靶点，特别是微管，以防止病理情况，如快速分裂的肿瘤细胞或在其他情况下有利于细胞分化的过程。在这篇综述中，我们将解决一些经典的和新的方面的关键调控功能的热休克蛋白和免疫亲作为管家因子的细胞骨架网络。
Cytoskeletal structure is continually remodeled to accommodate normal cell growth and to respond to pathophysiological cues. As a consequence, several cytoskeleton-interacting proteins become involved in a variety of cellular processes such as cell growth and division, cell movement, vesicle transportation, cellular organelle location and function, localization and distribution of membrane receptors, and cell-cell communication. Molecular chaperones and immunophilins are counted among the most important proteins that interact closely with the cytoskeleton network, in particular with microtubules and microtubule-associated factors. In several situations, heat-shock proteins and immunophilins work together as a functionally active heterocomplex, although both types of proteins also show independent actions. In circumstances where homeostasis is affected by environmental stresses or due to genetic alterations, chaperone proteins help to stabilize the system. Molecular chaperones facilitate the assembly, disassembly and/or folding/refolding of cytoskeletal proteins, so they prevent aberrant protein aggregation. Nonetheless, the roles of heat-shock proteins and immunophilins are not limited to solve abnormal situations, but they also have an active participation during the normal differentiation process of the cell and are key factors for many structural and functional rearrangements during this course of action. Cytoskeleton modifications leading to altered localization of nuclear factors may result in loss- or gain-of-function of such factors, which affects the cell cycle and cell development. Therefore, cytoskeletal components are attractive therapeutic targets, particularly microtubules, to prevent pathological situations such as rapidly dividing tumour cells or to favor the process of cell differentiation in other cases. In this review we will address some classical and novel aspects of key regulatory functions of heat-shock proteins and immunophilins as housekeeping factors of the cytoskeletal network.
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影响因子：
5.6
作者：
Aravind, L;Koonin, EV
通讯作者：
Koonin, EV
影响因子：
4.4
作者：
Bechtold, DA;Brown, IR
通讯作者：
Brown, IR
影响因子：
64.5
作者：
Albanèse, V;Yam, AYW;Frydman, J
通讯作者：
Frydman, J
DOI：
10.1073/pnas.1010176107
发表时间：
2010-11-16
影响因子：
11.1
作者：
Aylett, Christopher H. S.;Wang, Qing;Loewe, Jan
通讯作者：
Loewe, Jan
影响因子：
2.9
作者：
Banerjee, Ananya;Periyasamy, Sumudra;Wolf, Irene M.;Hinds, Terry D., Jr.;Yong, Weidong;Shou, Weinian;Sanchez, Edwin R.
通讯作者：
Sanchez, Edwin R.