Comparison of autoantibody-positive and autoantibody-negative pediatric participants enrolled in the T1D Exchange clinic registry.
Comparison of autoantibody-positive and autoantibody-negative pediatric participants enrolled in the T1D Exchange clinic registry.
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DOI：
10.1111/1753-0407.12031
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发表时间：
2013-06
影响因子：
4.5
通讯作者：
Beck RW
中科院分区：
文献类型：
--
作者：
Gerard-Gonzalez A;Gitelman SE;Cheng P;Dubose SN;Miller KM;Olson BA;Redondo MJ;Steck AK;Beck RW
比较 T1D Exchange 诊所登记处 18 岁以下 1 型糖尿病 (T1D) 自身抗体 (aAb) 阳性和阴性病例的特征。 aAb 阳性状态 (n = 6239) 要求至少一项 aAb 呈阳性； aAb 阴性状态 (n = 485) 需要至少两种不同 aAb 的测试结果为阴性。与 aAb 阳性组相比，aAb 阴性组的男性百分比较高（58% vs 51%；P = 0.002），每日总胰岛素剂量较低（P = 0.003），但两组的种族分布、诊断年龄、T1D 家族史、诊断时酮症酸中毒、诊断时和最近一次就诊时的体重指数以及当前 HbA1c 的分布相似。患有 T1D 的 aAb 阴性儿童比 aAb 阳性儿童更有可能患有男性和较低的每日胰岛素总剂量，但没有发现其他显着特征。进一步检查 aAb 阴性病例的特征可能有助于表征 T1D 的异质性。
To compare characteristics of autoantibody (aAb)-positive and -negative cases of type 1 diabetes (T1D) <18 years old in the T1D Exchange clinic registry. An aAb-positive status (n = 6239) required at least one of the aAbs to be positive; an aAb-negative status (n = 485) required negative results on testing of at least two different aAbs. The percentage of males was higher (58% vs 51%; P = 0.002) and total daily insulin dose lower (P = 0.003) in aAb-negative compared with aAb-positive groups, but both groups had similar distributions of race–ethnicity, diagnosis age, family history of T1D, ketoacidosis at diagnosis, body mass index at diagnosis and at most recent office visit, and current HbA1c. Male gender and lower total daily insulin dose were more likely in aAb-negative than aAb-positive children with T1D, but no other distinguishing characteristics were identified. Further examination of characteristics of aAb-negative cases may help characterize the heterogeneous nature of T1D.
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影响因子：
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