LncRNAs: The Ideal Composer of the Melody for Life

LncRNAs: The Ideal Composer of the Melody for Life
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LncRNA:生命旋律的理想作曲家

DOI:
10.11648/j.bs.20160202.11
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发表时间:
2016-06
期刊:
Biomedical Sciences
影响因子:
--
通讯作者:
Xiaoyuan Song
Xiaoyuan Song
中科院分区:
其他
文献类型:
--
作者:
Qingyu Cheng;Shengwei Ke;A. R. Ghanam;Xiaoyuan Song

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长链非编码rna (lncNRAs)作为基因组的主要转录本,正成为打开通往新视野的无形之门不可或缺的关键,这促使人们改变了以往认为lncrna是转录噪音和副产物的观点。然而,最令人困惑的事实是,尽管它们对许多生物过程和各种人类疾病的普遍调节,但它们的确切功能仍不清楚。本文综述了lncrna在不同水平上的调控作用,揭示了相关疾病的分子机制和发病机制。
Long noncoding RNAs (lncNRAs), as major transcripts from the genome, are becoming indispensable keys to invisible doors linking to a new horizon, prompting a shift in the previous thoughts that lncRNAs are the transcriptional noises and by-products. The most puzzling fact, however, is that in spite of their pervasive regulation of many biological processes and diverse human diseases, their exact functions are still unclear. Here we review the regulations by lncRNAs at different levels, revealing some insights upon the molecular mechanisms and pathogenesis of related diseases.
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