Depth-Encoded Spectral Domain Phase Microscopy for Simultaneous Multi-Site Nanoscale Optical Measurements.
Depth-Encoded Spectral Domain Phase Microscopy for Simultaneous Multi-Site Nanoscale Optical Measurements.
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DOI：
10.1016/j.optcom.2011.06.001
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发表时间：
2011-09-01
影响因子：
2.4
通讯作者：
Izatt, Joseph A.
中科院分区：
文献类型：
--
作者：
Hendargo, Hansford C.;Bower, Bradley A.;Reinstein, Alex S.;Shepherd, Neal;Tao, Yuankai K.;Izatt, Joseph A.
Spectral domain phase microscopy (SDPM) is an extension of spectral domain optical coherence tomography (SDOCT) that exploits the extraordinary phase stability of spectrometer-based systems with common-path geometry to resolve sub-wavelength displacements within a sample volume. This technique has been implemented for high resolution axial displacement and velocity measurements in biological samples, but since axial displacement information is acquired serially along the lateral dimension, it has been unable to measure fast temporal dynamics in extended samples. Depth-Encoded SDPM (DESDPM) uses multiple sample arms with unevenly spaced common path reference reflectors to multiplex independent SDPM signals from separate lateral positions on a sample simultaneously using a single interferometer, thereby reducing the time required to detect unique optical events to the integration period of the detector. Here, we introduce DESDPM and demonstrate the ability to acquire useful phase data concurrently at two laterally separated locations in a phantom sample as well as a biological preparation of spontaneously beating chick cardiomyocytes. DESDPM may be a useful tool for imaging fast cellular phenomena such as nervous conduction velocity or contractile motion.
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影响因子：
3.6
作者：
Wang, Hui;Pan, Yinsheng;Rollins, Andrew M.
通讯作者：
Rollins, Andrew M.
影响因子：
3.8
作者：
Yun, SH;Tearney, GJ;de Boer, JF
通讯作者：
de Boer, JF
影响因子：
3.8
作者：
Bachmann, Adrian H.;Michaely, Roland;Leitgeb, Rainer A.
通讯作者：
Leitgeb, Rainer A.
影响因子：
3.6
作者：
Nezam, S. M. R. Motaghian;Vakoc, B. J.;Bouma, B. E.
通讯作者：
Bouma, B. E.
影响因子：
3.5
作者：
Davis, AM;Choma, MA;Izatt, JA
通讯作者：
Izatt, JA