Childhood socioeconomic disadvantage is associated with lower mortality in older Japanese men: the JAGES cohort study.
Childhood socioeconomic disadvantage is associated with lower mortality in older Japanese men: the JAGES cohort study.
复制标题
DOI：
10.1093/ije/dyw146
复制
发表时间：
2016-08
影响因子：
7.7
通讯作者：
Fujiwara T
中科院分区：
文献类型：
--
作者：
Tani Y;Kondo N;Nagamine Y;Shinozaki T;Kondo K;Kawachi I;Fujiwara T
背景：儿童期社会经济劣势与成年期死亡风险增加有关。然而，以前的大多数研究都集中在西方环境中的中年人身上。在这里，我们试图研究儿童社会经济地位（SES）和死亡率之间的关系，在健康的老年日本成年人。研究方法：我们对日本老年学评估研究（JAGES）的参与者进行了为期3年的随访，该研究是一项基于65至103岁日本成年人的人群队列研究。通过基线调查评估儿童SES。对2010年至2013年15449名受访者（7143名男性和8306名女性）的死亡率进行了分析。使用考克斯回归模型估计死亡风险的风险比（HR）。结果：在3年随访期间，共有754例死亡。较低的儿童社会经济地位与男性较低的死亡率显著相关，但在女性中则不然。与在更宽松的童年社会经济环境中长大的男性相比，来自低童年社会经济地位背景的男性的年龄调整HR为0.75 [95%置信区间（CI）：0.56-1.00]。在调整身高、教育、成人SES、居住地、健康行为、疾病状态和当前社会关系后，这种关联仍然显著（HR = 0.64; 95%CI 0.47-0.87）。与65-74岁的男性相比，75岁或以上的男性中这种关联更强，HR = 0.67（95% CI：0.47-0.95），HR = 0.90（95% CI：0.54-1.51）。结论：儿童期社会经济劣势与75岁以上男性的死亡率较低有关，这可能是由于选择性生存，或者是由于这一代日本男性的儿童期体育训练或战后热量限制。
Background: Childhood socioeconomic disadvantage has been previously linked to increased mortality risk in adulthood. However, most previous studies have focused on middle-aged adults in Western contexts. Here, we sought to examine the association between childhood socioeconomic status (SES) and mortality among healthy older Japanese adults. Methods: We conducted a 3-year follow-up of participants in the Japan Gerontological Evaluation Study (JAGES), a population-based cohort of 65- to 103-year-old Japanese adults. Childhood SES was assessed by survey at baseline. Mortality from 2010 to 2013 was analysed for 15 449 respondents (7143 men and 8306 women). Cox regression models were used to estimate hazard ratios (HR) for risk of death. Results: A total of 754 deaths occurred during the 3-year follow-up. Lower childhood SES was significantly associated with lower mortality in men, but not in women. Compared with men growing up in more advantaged childhood socioeconomic circumstances, the age-adjusted HR for men from low childhood SES backgrounds was 0.75 [95% confidence interval (CI): 0.56–1.00]. The association remained significant after adjustment for height, education, adult SES, municipalities of residence, health behaviours, disease status and current social relationships (HR = 0.64; 95% CI 0.47–0.87). This association was stronger among men aged 75 years or older, HR = 0.67 (95% CI: 0.47–0.95), compared with men aged 65–74 years, HR = 0.90 (95% CI: 0.54–1.51). Conclusions: Childhood socioeconomic disadvantage is associated with lower mortality among men aged 75 years or older, which may be due to selective survival, or alternatively to childhood physical training or postwar calorie restriction in this generation of Japanese males.
登录
查看更多内容
影响因子：
6.3
作者：
Claussen, B;Smith, GD;Thelle, D
通讯作者：
Thelle, D
影响因子：
3.5
作者：
Johnson, NE
通讯作者：
Johnson, NE
DOI：
10.1126/science.1173635
发表时间：
2009-07-10
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Colman RJ;Anderson RM;Johnson SC;Kastman EK;Kosmatka KJ;Beasley TM;Allison DB;Cruzen C;Simmons HA;Kemnitz JW;Weindruch R
通讯作者：
Weindruch R
影响因子：
64.8
作者：
Mattison, Julie A.;Roth, George S.;Beasley, T. Mark;Tilmont, Edward M.;Handy, April M.;Herbert, Richard L.;Longo, Dan L.;Allison, David B.;Young, Jennifer E.;Bryant, Mark;Barnard, Dennis;Ward, Walter F.;Qi, Wenbo;Ingram, Donald K.;de Cabo, Rafael
通讯作者：
de Cabo, Rafael
影响因子：
4.5
作者：
Aida J;Kondo K;Hirai H;Subramanian SV;Murata C;Kondo N;Ichida Y;Shirai K;Osaka K
通讯作者：
Osaka K