Geomagnetic disturbances reduce heart rate variability in the Normative Aging Study.
Geomagnetic disturbances reduce heart rate variability in the Normative Aging Study.
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DOI：
10.1016/j.scitotenv.2022.156235
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发表时间：
2022-09-15
影响因子：
9.8
通讯作者：
Koutrakis, Petros
中科院分区：
文献类型：
--
作者：
Vieira, Carolina L. Zilli;Chen, Kelly;Garshick, Eric;Liu, Man;Vokonas, Pantel;Ljungman, Petter;Schwartz, Joel;Koutrakis, Petros
关键词：
太阳和地磁活动(GA)与心血管(CVD)事件的增加有关。我们假设心率变异性(HRV)可能是心血管疾病风险增加和强烈地磁干扰(GMD)之间的生物学机制。为了评估GA和强烈的GMD对809名参加标准老龄化研究(大波士顿地区)的老年男性[平均年龄74.5岁(SD=6.8)]的HRV的影响，我们使用混合效应回归模型进行重复测量。我们评估了两个HRV结果：连续正常至正常间期的均方差的平方根(r-MSSD)和正常至正常的心跳间期(以毫秒为单位)的标准差(SDNN)。我们还比较了Kp和HRV在合并和不合并糖尿病和冠心病(CHD)的患者中的相关性。我们使用来自中纬度的全球行星K指数(Kp)数据作为GA和GMD(>；75th Kp)参数，这些参数来自美国国家海洋和大气管理局的空间天气预报中心。我们发现，持续和较高的Kp对暴露至心电记录前24小时的HRV降低有近乎即时的影响。检查前15小时Kp增加第75个百分位数与r-MSSD的−变化14.7ms(95 CI：−23.1，−6.3，p值=0.0007)和SDNN的−8.2ms变化(95 CI：−13.9，−2.5，p值=0.006)相关。在调整了事件发生前暴露窗口内的空气污染物模型后，相关性仍然相似。在严重的GMD时期，冠心病和非糖尿病患者之间的相关性更强。这是首次在大规模流行病学队列中证明地磁活动对较长时期内心率变异性降低的潜在不利影响的研究，这可能在不同人群中具有重要的临床意义。
Solar and geomagnetic activity (GA) have been linked to increased cardiovascular (CVD) events. We hypothesize that heart rate variability (HRV) may be the biological mechanism between increased CVD risk and intense geomagnetic disturbances (GMD). To evaluate the impact of GA and intense GMD on HRV in 809 elderly men [age mean 74.5 (SD = 6.8)] enrolled in the Normative Aging Study (Greater Boston Area), we performed repeated-measures using mixed-effects regression models. We evaluated two HRV outcomes: the square root of the mean squared differences of successive normal-to-normal intervals (r-MSSD) and the standard deviation of normal-to-normal heartbeat intervals (SDNN) in milliseconds (ms). We also compared the associations between Kp and HRV in patients with and without comorbidities such as diabetes and coronary heart diseases (CHD). We used data on global planetary K-Index (Kp) from middle latitudes as a GA and GMD (>75th Kp) parameters from the National Oceanic and Atmospheric Agency’s Space Weather Prediction Center. We found a near immediate effect of continuous and higher Kp on reduced HRV for exposures up to 24 h prior to electrocardiogram recording. A 75th percentile increase in 15-hour Kp prior the examination was associated with a −14.7 ms change in r-MSSD (95 CI: −23.1, −6.3, p-value = 0.0007) and a −8.2 ms change in SDNN (95 CI: −13.9, −2.5, p-value = 0.006). The associations remained similar after adjusting the models for air pollutants over the exposure window prior to the event. In periods of intense GMD, the associations were stronger in patients with CHD and non-diabetes. This is the first study to demonstrate the potential adverse effects of geomagnetic activity on reduced heart rate variability in a large epidemiologic cohort over an extended period, which may have important clinical implications among different populations.
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影响因子：
64.8
作者：
Hasegawa, H;Fujimoto, M;TanDokoro, R
通讯作者：
TanDokoro, R
DOI：
10.1016/j.jastp.2014.01.020
发表时间：
2014-04-01
影响因子：
1.9
作者：
Krylov, Viacheslav V.;Zotov, Oleg D.;Osipova, Elena A.
通讯作者：
Osipova, Elena A.
影响因子：
37.8
作者：
Bettoni, M;Zimmermann, M
通讯作者：
Zimmermann, M
影响因子：
4.6
作者：
Alabdulgader A;McCraty R;Atkinson M;Dobyns Y;Vainoras A;Ragulskis M;Stolc V
通讯作者：
Stolc V
DOI：
10.3155/1047-3289.60.11.1327
发表时间：
2010-11
期刊：
Journal of the Air & Waste Management Association (1995)
影响因子：
--
作者：
Kang CM;Koutrakis P;Suh HH
通讯作者：
Suh HH