Reactome: a knowledge base of biologic pathways and processes.

Reactome: a knowledge base of biologic pathways and processes.
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Reactome:生物学途径和过程的知识库。

DOI:
10.1186/gb-2007-8-3-r39
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发表时间:
2007
期刊:
影响因子:
12.3
通讯作者:
Stein, Lincoln
Stein, Lincoln
中科院分区:
生物学1区
文献类型:
--
作者:
Vastrik, Imre;D'Eustachio, Peter;Schmidt, Esther;Joshi-Tope, Geeta;Gopinath, Gopal;Croft, David;de Bono, Bernard;Gillespie, Marc;Jassal, Bijay;Lewis, Suzanna;Matthews, Lisa;Wu, Guanming;Birney, Ewan;Stein, Lincoln

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Reactome是一个人类途径数据的在线精选资源,可以用来推断非人类物种的同等反应,并作为帮助解释微阵列和其他高通量数据集的工具。Reactome http://www.reactome.org,是人类途径数据的在线精选资源,为整个生物反应网络的计算提供了基础设施。我们使用Reactome来推断多个非人类物种中的等价反应,并提供了关于远缘关系的真核生物酿酒酵母的这些推断反应的可靠性的数据。最后,我们描述了Reactome作为学习资源和计算工具的使用,以帮助解释微阵列和类似的大规模数据集。
Reactome, an online curated resource for human pathway data, can be used to infer equivalent reactions in non-human species and as a tool to aid in the interpretation of microarrays and other high-throughput data sets. Reactome http://www.reactome.org, an online curated resource for human pathway data, provides infrastructure for computation across the biologic reaction network. We use Reactome to infer equivalent reactions in multiple nonhuman species, and present data on the reliability of these inferred reactions for the distantly related eukaryote Saccharomyces cerevisiae. Finally, we describe the use of Reactome both as a learning resource and as a computational tool to aid in the interpretation of microarrays and similar large-scale datasets.
DOI: 10.1016/s0014-5793(03)01104-9
发表时间: 2003-11-27
期刊: FEBS LETTERS
影响因子: 3.5
作者:
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