Correspondence between bone mineral density and intervertebral disc degeneration across age and sex.
Correspondence between bone mineral density and intervertebral disc degeneration across age and sex.
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DOI：
10.1007/s11657-018-0538-1
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发表时间：
2018-11-12
影响因子：
3
通讯作者：
Morgan EF
中科院分区：
文献类型：
--
作者：
Kaiser J;Allaire B;Fein PM;Lu D;Jarraya M;Guermazi A;Demissie S;Samelson EJ;Bouxsein ML;Morgan EF
虽然椎骨骨密度(BMD)在老化脊柱中的下降已得到证实，但年龄对椎骨内BMD分布的影响程度尚不清楚。测量局部骨密度(RBMD)可能会改善对椎体强度的预测，并提示椎骨如何适应椎间盘退变。因此，我们的目标是评估RBMD值与年龄、性别和椎间隙高度丢失(DHL)之间的关系。我们测量了来自Framingham心脏研究(41-83岁，181 M/196 F)的377名参与者的L3椎体的RBMD。QCT图像测量骨密度积分(Int.BMD)和骨小梁密度(Tb.BMD)。从椎体开始计算RBMD比值(前/后、上/中横、下/中横、中央/外)。放射科医生对相邻的椎间盘(L2-L3和L3-L4)进行了DHL严重程度评分。Int.BMD和Tb.BMD均与年龄有关，但女性(Int.BMD：−每年2.6 mg/cm~3；Tb.BMD：−2.6 mg/cm~3/年)的下降幅度大于男性(Int.BMD：−每年0.5 mg/cm~3；Tb.BMD：−1.2 mg/cm~3/年)。中央/外部(−0.027/十)和上/中横径(−0.018/十)的RBMD比率与年龄呈负相关，男性和女性的趋势相似。在调整了年龄和性别后，更高的Int.BMD或Tb.BMD与DHL的发病几率增加相关。低中央/外比、高前/柱比和高上/中/横比也与DHL的发病几率增加有关。我们的结果表明，L3椎体内的骨分布在年龄上是不同的，但在性别之间没有差异，并且与椎间盘退变有关。椎骨内骨组织的分布可以独立于平均密度调节椎体强度，并可能随着年龄和椎间盘退变而变化。我们的结果表明，与年龄相关的骨密度下降在空间上是不均匀的，并与椎间盘健康相关，这表明关节盘和椎体之间存在机械相互作用。
While the decline of bone mineral density (BMD) in the aging spine is well established, the extent to which age influences BMD distribution within the vertebra is less clear. Measures of regional BMD (rBMD) may improve predictions of vertebral strength and suggest how vertebrae might adapt with intervertebral disc degeneration. Thus, we aimed to assess how rBMD values were associated with age, sex and disc height loss (DHL). We measured rBMD in the L3 vertebra of 377 participants from the Framingham Heart Study (41-83 years, 181 M/196 F). Integral (Int.BMD) and trabecular BMD (Tb.BMD) were measured from QCT images. rBMD ratios (anterior/posterior, superior/mid-transverse, inferior/mid-transverse, and central/outer) were calculated from the centrum. A radiologist assigned a DHL severity score to adjacent intervertebral discs (L2-L3 and L3-L4). Int.BMD and Tb.BMD were both associated with age, though the decrease across age was greater in women (Int.BMD: −2.6 mg/cm3 per year; Tb.BMD: −2.6 mg/cm3 per year) than men (Int.BMD: −0.5 mg/cm3 per year; Tb.BMD: −1.2 mg/cm3 per year). The central/outer (−0.027/decade) and superior/mid-transverse (−0.018/decade) rBMD ratios were negatively associated with age, with similar trends in men and women. Higher Int.BMD or Tb.BMD was associated with increased odds of DHL after adjusting for age and sex. Low central/outer ratio and high anterior/poster and superior/mid-transverse ratios were also associated with increased odds of DHL. Our results indicate that the distribution of bone within the L3 vertebra is different across age, but not between sexes, and is associated with disc degeneration. The distribution of bone tissue within the vertebra can modulate vertebral strength independently of average density and may change with age and disc degeneration. Our results show that the age-associated decrease in bone density is spatially non-uniform and associated with disc health, suggesting a mechanistic interplay between disc and vertebra.
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影响因子：
4
作者：
Chen, H.;Shoumura, S.;Bunai, Y.
通讯作者：
Bunai, Y.
DOI：
10.2106/00004623-199072030-00013
发表时间：
1990-03-01
影响因子：
5.3
作者：
BODEN, SD;DAVIS, DO;WIESEL, SW
通讯作者：
WIESEL, SW
影响因子：
4.1
作者：
GROTE, HJ;AMLING, M;DELLING, G
通讯作者：
DELLING, G
影响因子：
4.1
作者：
Kanis, JA;Johnell, O;Dawson, A
通讯作者：
Dawson, A
影响因子：
6.2
作者：
Cheng, XG;Nicholson, PHF;Dequeker, J
通讯作者：
Dequeker, J