Stereo-EEG-guided network modulation for psychiatric disorders: Surgical considerations.
Stereo-EEG-guided network modulation for psychiatric disorders: Surgical considerations.
复制标题
立体脑电引导的网络调制治疗精神障碍：手术考虑。
DOI：
10.1016/j.brs.2023.07.057
复制
发表时间：
2023-11
影响因子：
7.7
通讯作者：
Pouratian, Nader
中科院分区：
文献类型：
--
作者：
Sheth, Sameer A.;Shofty, Ben;Allawala, Anusha;Xiao, Jiayang;Adkinson, Joshua A.;Mathura, Raissa K.;Pirtle, Victoria;Myers, John;Oswalt, Denise;Provenza, Nicole R.;Giridharan, Nisha;Noecker, Angela M.;Banks, Garrett P.;Gadot, Ron;Najera, Ricardo A.;Anand, Adrish;Devara, Ethan;Dang, Huy;Bartoli, Eleonora;Watrous, Andrew;Cohn, Jeffrey;Borton, David;Mathew, Sanjay J.;Mcintyre, Cameron C.;Goodman, Wayne;Bijanki, Kelly;Pouratian, Nader
关键词：
Deep brain stimulation (DBS) and other neuromodulatory techniques are being increasingly utilized to treat refractory neurologic and psychiatric disorders. /Hypothesis: To better understand the circuit-level pathophysiology of treatment-resistant depression (TRD) and treat the network-level dysfunction inherent to this challenging disorder, we adopted an approach of inpatient intracranial monitoring borrowed from the epilepsy surgery field. We implanted 3 patients with 4 DBS leads (bilateral pair in both the ventral capsule/ventral striatum and subcallosal cingulate) and 10 stereo-electroencephalography (sEEG) electrodes targeting depression-relevant network regions. For surgical planning, we used an interactive, holographic visualization platform to appreciate the 3D anatomy and connectivity. In the initial surgery, we placed the DBS leads and sEEG electrodes using robotic stereotaxy. Subjects were then admitted to an inpatient monitoring unit for depression-specific neurophysiological assessments. Following these investigations, subjects returned to the OR to remove the sEEG electrodes and internalize the DBS leads to implanted pulse generators. Intraoperative testing revealed positive valence responses in all 3 subjects that helped verify targeting. Given the importance of the network-based hypotheses we were testing, we required accurate adherence to the surgical plan (to engage DBS and sEEG targets) and stability of DBS lead rotational position (to ensure that stimulation field estimates of the directional leads used during inpatient monitoring were relevant chronically), both of which we confirmed (mean radial error 1.2±0.9 mm; mean rotation 3.6±2.6°). This novel hybrid sEEG-DBS approach allows detailed study of the neurophysiological substrates of complex neuropsychiatric disorders.
登录
查看更多内容
影响因子：
10.6
作者：
Goodman WK;Foote KD;Greenberg BD;Ricciuti N;Bauer R;Ward H;Shapira NA;Wu SS;Hill CL;Rasmussen SA;Okun MS
通讯作者：
Okun MS
影响因子：
2.3
作者：
Tsolaki, Evangelia;Espinoza, Randall;Pouratian, Nader
通讯作者：
Pouratian, Nader
影响因子：
4.1
作者：
Youngerman, Brett E.;Chan, Andrew K.;Sheth, Sameer A.
通讯作者：
Sheth, Sameer A.
影响因子：
10.6
作者：
Riva-Posse P;Choi KS;Holtzheimer PE;McIntyre CC;Gross RE;Chaturvedi A;Crowell AL;Garlow SJ;Rajendra JK;Mayberg HS
通讯作者：
Mayberg HS
长期的生态评估对强迫症的行为标记同步颅内电生理学。
影响因子：
82.9
作者：
Provenza NR;Sheth SA;Dastin-van Rijn EM;Mathura RK;Ding Y;Vogt GS;Avendano-Ortega M;Ramakrishnan N;Peled N;Gelin LFF;Xing D;Jeni LA;Ertugrul IO;Barrios-Anderson A;Matteson E;Wiese AD;Xu J;Viswanathan A;Harrison MT;Bijanki KR;Storch EA;Cohn JF;Goodman WK;Borton DA
通讯作者：
Borton DA