Long-term ecological assessment of intracranial electrophysiology synchronized to behavioral markers in obsessive-compulsive disorder.
Long-term ecological assessment of intracranial electrophysiology synchronized to behavioral markers in obsessive-compulsive disorder.
复制标题
长期的生态评估对强迫症的行为标记同步颅内电生理学。
DOI：
10.1038/s41591-021-01550-z
复制
发表时间：
2021-12
期刊：
影响因子：
82.9
通讯作者：
Borton DA
中科院分区：
文献类型：
--
作者：
Provenza NR;Sheth SA;Dastin-van Rijn EM;Mathura RK;Ding Y;Vogt GS;Avendano-Ortega M;Ramakrishnan N;Peled N;Gelin LFF;Xing D;Jeni LA;Ertugrul IO;Barrios-Anderson A;Matteson E;Wiese AD;Xu J;Viswanathan A;Harrison MT;Bijanki KR;Storch EA;Cohn JF;Goodman WK;Borton DA
Detection of neural signatures related to pathological behavioral states could enable adaptive deep brain stimulation (aDBS), a potential strategy for improving efficacy of DBS for neurological and psychiatric disorders. This approach requires identifying neural biomarkers of relevant behavioral states, a task best performed in ecologically valid environments. Here, in human participants with obsessive-compulsive disorder (OCD) implanted with recording-capable DBS devices, we synchronized chronic ventral striatum local field potentials (LFP) with relevant, disease-specific behaviors. We captured over 1,000 hours of LFP in the clinic and at home during unstructured activity, as well as during DBS and exposure therapy. The wide range of symptom severity over which the data were captured allowed us to identify candidate neural biomarkers of OCD symptom intensity. This work demonstrates the feasibility and utility of capturing chronic intracranial electrophysiology during daily symptom fluctuations to enable neural biomarker identification, a prerequisite for future development of aDBS for OCD and other psychiatric disorders.
登录
查看更多内容
影响因子：
3.7
作者：
Baker, Jason K.;Haltigan, John D.;Messinger, Daniel
通讯作者：
Messinger, Daniel
影响因子：
17.7
作者：
Denys, Damiaan;Graat, Ilse;Schuurman, Rick
通讯作者：
Schuurman, Rick
影响因子：
7.7
作者：
Dibeklioglu H;Hammal Z;Cohn JF
通讯作者：
Cohn JF
影响因子：
5.7
作者：
Fischl, Bruce
通讯作者：
Fischl, Bruce
影响因子：
10.6
作者：
Figee, Martijn;Vink, Matthijs;Denys, Damiaan
通讯作者：
Denys, Damiaan