Much More than M1 and M2 Macrophages, There are also CD169(+) and TCR(+) Macrophages.
Much More than M1 and M2 Macrophages, There are also CD169(+) and TCR(+) Macrophages.
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DOI：
10.3389/fimmu.2015.00263
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发表时间：
2015
影响因子：
7.3
通讯作者：
Garcia I
中科院分区：
文献类型：
--
作者：
Chávez-Galán L;Olleros ML;Vesin D;Garcia I
单核细胞被认为是单核吞噬系统的前体细胞，巨噬细胞是该细胞系统的主要成员之一。巨噬细胞通过直接参与病原体消除或在无菌炎症条件下修复组织，在维持生物体完整性方面发挥高度不同的作用。巨噬细胞有不同的亚群，每一个都有自己的特点和功能。在这篇综述中，我们总结了目前的知识极化的巨噬细胞，允许生成的亚群称为经典活化的巨噬细胞或M1和替代活化的巨噬细胞或M2。此外，还有巨噬细胞，它们的起源和特征仍然不清楚，但已经参与了一些人类病理学的主要参与者。因此，我们还回顾了其他三种巨噬细胞：肿瘤相关巨噬细胞，CD169+巨噬细胞和最近命名的TCR+巨噬细胞。基于文献，我们提供了这些巨噬细胞亚群的分子特征及其在几种人类病理学如癌症、传染病、肥胖和哮喘中的具体参与的信息。巨噬细胞亚群的精细表征可用于设计新策略，补充那些已经建立的用于使用巨噬细胞作为治疗靶点治疗疾病的策略。
Monocytes are considered to be precursor cells of the mononuclear phagocytic system, and macrophages are one of the leading members of this cellular system. Macrophages play highly diverse roles in maintaining an organism’s integrity by either directly participating in pathogen elimination or repairing tissue under sterile inflammatory conditions. There are different subpopulations of macrophages and each one has its own characteristics and functions. In this review, we summarize present knowledge on the polarization of macrophages that allows the generation of subpopulations called classically activated macrophages or M1 and alternative activated macrophages or M2. Furthermore, there are macrophages that their origin and characterization still remain unclear but have been involved as main players in some human pathologies. Thus, we also review three other categories of macrophages: tumor-associated macrophages, CD169+ macrophages, and the recently named TCR+ macrophages. Based on the literature, we provide information on the molecular characterization of these macrophage subpopulations and their specific involvement in several human pathologies such as cancer, infectious diseases, obesity, and asthma. The refined characterization of the macrophage subpopulations can be useful in designing new strategies, supplementing those already established for the treatment of diseases using macrophages as a therapeutic target.
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影响因子：
6.4
作者：
Collin M;McGovern N;Haniffa M
通讯作者：
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影响因子：
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影响因子：
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Kaminski WE