Stress-induced plasticity of dynamic collagen networks.
Stress-induced plasticity of dynamic collagen networks.
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DOI：
10.1038/s41467-017-01011-7
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发表时间：
2017-10-10
影响因子：
16.6
通讯作者：
Sun B
中科院分区：
文献类型：
--
作者：
Kim J;Feng J;Jones CAR;Mao X;Sander LM;Levine H;Sun B
组织的结构和力学不断受到源自细胞的内源力的扰动，同时调节许多重要的细胞功能，如迁移、分化和生长。在这里，我们展示了 3D 胶原凝胶（结缔组织和细胞外基质 (ECM) 的主要成分）通过细胞牵引力以及宏观应变进行显着且不可逆的重塑。为了理解这种 ECM 可塑性，我们开发了一个计算模型，该模型考虑了 ECM 纤维的滑动和合并。我们通过实验证实了模型的预测。我们的结果表明细胞牵引力在发育和癌症进展过程中对其宿主 ECM 产生深远影响，并表明 3D 纤维基质中细胞间通讯的间接机械通道。组织的结构和力学不断受到源自细胞的内源力的扰动。作者在此表明，3D 胶原凝胶（结缔组织和细胞外基质的主要成分）会通过细胞牵引力和宏观应变进行显着且不可逆的重塑。
The structure and mechanics of tissues is constantly perturbed by endogenous forces originated from cells, and at the same time regulate many important cellular functions such as migration, differentiation, and growth. Here we show that 3D collagen gels, major components of connective tissues and extracellular matrix (ECM), are significantly and irreversibly remodeled by cellular traction forces, as well as by macroscopic strains. To understand this ECM plasticity, we develop a computational model that takes into account the sliding and merging of ECM fibers. We have confirmed the model predictions with experiment. Our results suggest the profound impacts of cellular traction forces on their host ECM during development and cancer progression, and suggest indirect mechanical channels of cell-cell communications in 3D fibrous matrices. The structure and mechanics of tissues is constantly perturbed by endogenous forces originated from cells. Here the authors show that 3D collagen gels, major components of connective tissues and extracellular matrix, are significantly and irreversibly remodelled by cellular traction forces and by macroscopic strains.
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影响因子：
16.6
作者：
Chaudhuri O;Gu L;Darnell M;Klumpers D;Bencherif SA;Weaver JC;Huebsch N;Mooney DJ
通讯作者：
Mooney DJ
DOI：
10.1073/pnas.1504258112
发表时间：
2015-08-04
影响因子：
11.1
作者：
Licup, Albert James;Muenster, Stefan;MacKintosh, Fred C.
通讯作者：
MacKintosh, Fred C.
影响因子：
2.4
作者：
Mao, Xiaoming;Stenull, Olaf;Lubensky, T. C.
通讯作者：
Lubensky, T. C.
影响因子：
6
作者：
Conklin, Matthew W.;Eickhoff, Jens C.;Keely, Patricia J.
通讯作者：
Keely, Patricia J.
DOI：
10.1164/ajrccm.162.4.9912011
发表时间：
2000-10-01
影响因子：
24.7
作者：
Ebihara, T;Venkatesan, N;Ludwig, MS
通讯作者：
Ludwig, MS