Genetic Determinants in Airways Obstructive Diseases: The Case of Asthma Chronic Obstructive Pulmonary Disease Overlap.
Genetic Determinants in Airways Obstructive Diseases: The Case of Asthma Chronic Obstructive Pulmonary Disease Overlap.
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DOI：
10.1016/j.iac.2022.03.003
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发表时间：
2022-08
影响因子：
2.6
通讯作者：
Hersh, Craig P.
中科院分区：
文献类型：
--
作者：
Saferali, Aabida;Hersh, Craig P.
关键词：
随着样本量的不断增加，哮喘和COPD的全基因组关联研究（GWAS）发现多个遗传位点与这两种疾病相关。然而，哮喘和COPD之间几乎没有交叉位点。GWAS特别关注哮喘-COPD重叠（ACO），但由于样本量较小以及缺乏一致的ACO定义而受到限制，这也阻碍了临床和流行病学研究。其他基因组技术，如基因表达谱分析，是可行的较小的样本量。在COPD研究中对气道高反应性和过敏/T2炎症生物标志物的客观测量进行遗传分析可能是克服ACO定义局限性的另一种策略。
Genome-wide association studies (GWAS) of asthma and COPD with ever-increasing sample sizes have found multiple genetic loci associated with either disease. However, there are few intersecting loci between asthma and COPD. GWAS specifically focused on asthma-COPD overlap (ACO) have been limited by smaller sample sizes and the lack of a consistent definition of ACO that has also hampered clinical and epidemiological studies. Other genomic techniques, such as gene expression profiling, are feasible with smaller sample sizes. Genetic analyses of objective measures of airway hyperresponsiveness and allergy/T2 inflammation biomarkers in COPD studies may be another strategy to overcome limitations in ACO definitions.
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DOI：
10.1016/j.jaci.2021.09.011
发表时间：
2021-12
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
Daya M;Cox C;Acevedo N;Boorgula MP;Campbell M;Chavan S;Cho MH;David GL;Kachroo P;Lasky-Su J;Li X;McHugh CP;Qiao D;Rafaels N;Beck LA;Bleecker ER;Caraballo L;Cupples AL;Figueiredo CA;Gallo RL;Hanifin J;Hansel NN;Hata TR;Hersh CP;Knight-Madden J;Leung DYM;Guttman-Yassky E;Meyers DA;O'Connor G;Ober C;Ong PY;Ortega VE;Paller AS;Putcha N;Reed RM;Schneider LC;Silverman EK;Slifka MK;Spergel JM;Vasan RS;Viaud-Martinez KA;Watson H;Weiss ST;NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium;Ruczinski I;Beaty TH;Mathias RA;Barnes KC
通讯作者：
Barnes KC
DOI：
10.1183/09031936.00216013
发表时间：
2014-08
期刊：
The European respiratory journal
影响因子：
--
作者：
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通讯作者：
Hersh CP
DOI：
10.1016/j.jaci.2011.09.029
发表时间：
2012-03
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
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通讯作者：
O'Connor GT
影响因子：
30.8
作者：
Demenais F;Margaritte-Jeannin P;Barnes KC;Cookson WOC;Altmüller J;Ang W;Barr RG;Beaty TH;Becker AB;Beilby J;Bisgaard H;Bjornsdottir US;Bleecker E;Bønnelykke K;Boomsma DI;Bouzigon E;Brightling CE;Brossard M;Brusselle GG;Burchard E;Burkart KM;Bush A;Chan-Yeung M;Chung KF;Couto Alves A;Curtin JA;Custovic A;Daley D;de Jongste JC;Del-Rio-Navarro BE;Donohue KM;Duijts L;Eng C;Eriksson JG;Farrall M;Fedorova Y;Feenstra B;Ferreira MA;Australian Asthma Genetics Consortium (AAGC) collaborators;Freidin MB;Gajdos Z;Gauderman J;Gehring U;Geller F;Genuneit J;Gharib SA;Gilliland F;Granell R;Graves PE;Gudbjartsson DF;Haahtela T;Heckbert SR;Heederik D;Heinrich J;Heliövaara M;Henderson J;Himes BE;Hirose H;Hirschhorn JN;Hofman A;Holt P;Hottenga J;Hudson TJ;Hui J;Imboden M;Ivanov V;Jaddoe VWV;James A;Janson C;Jarvelin MR;Jarvis D;Jones G;Jonsdottir I;Jousilahti P;Kabesch M;Kähönen M;Kantor DB;Karunas AS;Khusnutdinova E;Koppelman GH;Kozyrskyj AL;Kreiner E;Kubo M;Kumar R;Kumar A;Kuokkanen M;Lahousse L;Laitinen T;Laprise C;Lathrop M;Lau S;Lee YA;Lehtimäki T;Letort S;Levin AM;Li G;Liang L;Loehr LR;London SJ;Loth DW;Manichaikul A;Marenholz I;Martinez FJ;Matheson MC;Mathias RA;Matsumoto K;Mbarek H;McArdle WL;Melbye M;Melén E;Meyers D;Michel S;Mohamdi H;Musk AW;Myers RA;Nieuwenhuis MAE;Noguchi E;O'Connor GT;Ogorodova LM;Palmer CD;Palotie A;Park JE;Pennell CE;Pershagen G;Polonikov A;Postma DS;Probst-Hensch N;Puzyrev VP;Raby BA;Raitakari OT;Ramasamy A;Rich SS;Robertson CF;Romieu I;Salam MT;Salomaa V;Schlünssen V;Scott R;Selivanova PA;Sigsgaard T;Simpson A;Siroux V;Smith LJ;Solodilova M;Standl M;Stefansson K;Strachan DP;Stricker BH;Takahashi A;Thompson PJ;Thorleifsson G;Thorsteinsdottir U;Tiesler CMT;Torgerson DG;Tsunoda T;Uitterlinden AG;van der Valk RJP;Vaysse A;Vedantam S;von Berg A;von Mutius E;Vonk JM;Waage J;Wareham NJ;Weiss ST;White WB;Wickman M;Widén E;Willemsen G;Williams LK;Wouters IM;Yang JJ;Zhao JH;Moffatt MF;Ober C;Nicolae DL
通讯作者：
Nicolae DL
影响因子：
64.5
作者：
Astle, William J.;Elding, Heather;Soranzo, Nicole
通讯作者：
Soranzo, Nicole