Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks.
Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks.
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DOI：
10.1038/s41588-017-0014-7
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发表时间：
2018-01
期刊：
影响因子：
30.8
通讯作者：
Nicolae DL
中科院分区：
文献类型：
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作者：
Demenais F;Margaritte-Jeannin P;Barnes KC;Cookson WOC;Altmüller J;Ang W;Barr RG;Beaty TH;Becker AB;Beilby J;Bisgaard H;Bjornsdottir US;Bleecker E;Bønnelykke K;Boomsma DI;Bouzigon E;Brightling CE;Brossard M;Brusselle GG;Burchard E;Burkart KM;Bush A;Chan-Yeung M;Chung KF;Couto Alves A;Curtin JA;Custovic A;Daley D;de Jongste JC;Del-Rio-Navarro BE;Donohue KM;Duijts L;Eng C;Eriksson JG;Farrall M;Fedorova Y;Feenstra B;Ferreira MA;Australian Asthma Genetics Consortium (AAGC) collaborators;Freidin MB;Gajdos Z;Gauderman J;Gehring U;Geller F;Genuneit J;Gharib SA;Gilliland F;Granell R;Graves PE;Gudbjartsson DF;Haahtela T;Heckbert SR;Heederik D;Heinrich J;Heliövaara M;Henderson J;Himes BE;Hirose H;Hirschhorn JN;Hofman A;Holt P;Hottenga J;Hudson TJ;Hui J;Imboden M;Ivanov V;Jaddoe VWV;James A;Janson C;Jarvelin MR;Jarvis D;Jones G;Jonsdottir I;Jousilahti P;Kabesch M;Kähönen M;Kantor DB;Karunas AS;Khusnutdinova E;Koppelman GH;Kozyrskyj AL;Kreiner E;Kubo M;Kumar R;Kumar A;Kuokkanen M;Lahousse L;Laitinen T;Laprise C;Lathrop M;Lau S;Lee YA;Lehtimäki T;Letort S;Levin AM;Li G;Liang L;Loehr LR;London SJ;Loth DW;Manichaikul A;Marenholz I;Martinez FJ;Matheson MC;Mathias RA;Matsumoto K;Mbarek H;McArdle WL;Melbye M;Melén E;Meyers D;Michel S;Mohamdi H;Musk AW;Myers RA;Nieuwenhuis MAE;Noguchi E;O'Connor GT;Ogorodova LM;Palmer CD;Palotie A;Park JE;Pennell CE;Pershagen G;Polonikov A;Postma DS;Probst-Hensch N;Puzyrev VP;Raby BA;Raitakari OT;Ramasamy A;Rich SS;Robertson CF;Romieu I;Salam MT;Salomaa V;Schlünssen V;Scott R;Selivanova PA;Sigsgaard T;Simpson A;Siroux V;Smith LJ;Solodilova M;Standl M;Stefansson K;Strachan DP;Stricker BH;Takahashi A;Thompson PJ;Thorleifsson G;Thorsteinsdottir U;Tiesler CMT;Torgerson DG;Tsunoda T;Uitterlinden AG;van der Valk RJP;Vaysse A;Vedantam S;von Berg A;von Mutius E;Vonk JM;Waage J;Wareham NJ;Weiss ST;White WB;Wickman M;Widén E;Willemsen G;Williams LK;Wouters IM;Yang JJ;Zhao JH;Moffatt MF;Ober C;Nicolae DL
我们通过对来自不同种族人群的全球哮喘全基因组关联研究（23，948例病例，118，538例对照）进行荟萃分析，检查了哮喘风险的常见变异。我们确定了5个新的哮喘位点，在两个已知的哮喘位点发现了另外两个新的关联，在两个先前与哮喘加花粉热共病有关的位点建立了哮喘关联，并确认了9个已知的位点。多效性的研究显示，自身免疫性和炎症性疾病的遗传变异有很大的重叠。增强子标记中哮喘风险位点的富集，特别是在免疫细胞中，表明这些位点在免疫相关机制的调节中起主要作用。
We examined common variation in asthma risk by conducting a meta-analysis of worldwide asthma genome-wide association studies (23,948 cases, 118,538 controls) from ethnically-diverse populations. We identified five new asthma loci, uncovered two additional novel associations at two known asthma loci, established asthma associations at two loci implicated previously in comorbidity of asthma plus hay fever, and confirmed nine known loci. Investigation of pleiotropy showed large overlaps in genetic variants with autoimmune and inflammatory diseases. Enrichment of asthma risk loci in enhancer marks, especially in immune cells, suggests a major role of these loci in the regulation of immune-related mechanisms.
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影响因子：
3.7
作者：
Hayes JE;Trynka G;Vijai J;Offit K;Raychaudhuri S;Klein RJ
通讯作者：
Klein RJ
影响因子：
14.2
作者：
Ferreira, Manuel A. R.;Matheson, Melanie C.;Tang, Clara S.;Granell, Raquel;Ang, Wei;Hui, Jennie;Kiefer, Amy K.;Duffy, David L.;Baltic, Svetlana;Danoy, Patrick;Bui, Minh;Price, Loren;Sly, Peter D.;Eriksson, Nicholas;Madden, Pamela A.;Abramson, Michael J.;Holt, Patrick G.;Heath, Andrew C.;Hunter, Michael;Musk, Bill;Robertson, Colin F.;Le Souef, Peter;Montgomery, Grant W.;Henderson, A. John;Tung, Joyce Y.;Dharmage, Shyamali C.;Brown, Matthew A.;James, Alan;Thompson, Philip J.;Pennell, Craig;Martin, Nicholas G.;Evans, David M.;Hinds, David A.;Hopper, John L.
通讯作者：
Hopper, John L.
影响因子：
4.5
作者：
Noguchi E;Sakamoto H;Hirota T;Ochiai K;Imoto Y;Sakashita M;Kurosaka F;Akasawa A;Yoshihara S;Kanno N;Yamada Y;Shimojo N;Kohno Y;Suzuki Y;Kang MJ;Kwon JW;Hong SJ;Inoue K;Goto Y;Yamashita F;Asada T;Hirose H;Saito I;Fujieda S;Hizawa N;Sakamoto T;Masuko H;Nakamura Y;Nomura I;Tamari M;Arinami T;Yoshida T;Saito H;Matsumoto K
通讯作者：
Matsumoto K
影响因子：
168.9
作者：
Ferreira, Manuel A. R.;Matheson, Melanie C.;Duffy, David L.;Marks, Guy B.;Hui, Jennie;Le Souef, Peter;Danoy, Patrick;Baltic, Svetlana;Nyholt, Dale R.;Jenkins, Mark;Hayden, Catherine;Willemsen, Gonneke;Ang, Wei;Kuokkanen, Mikko;Beilby, John;Cheah, Faang;de Geus, Eco J. C.;Ramasamy, Adaikalavan;Vedantam, Sailaja;Salomaa, Veikko;Madden, Pamela A.;Heath, Andrew C.;Hopper, John L.;Visscher, Peter M.;Musk, Bill;Leeder, Stephen R.;Jarvelin, Marjo-Riitta;Pennell, Craig;Boomsma, Dorret I.;Hirschhorn, Joel N.;Walters, Haydn;Martin, Nicholas G.;James, Alan;Jones, Graham;Abramson, Michael J.;Robertson, Colin F.;Dharmage, Shyamali C.;Brown, Matthew A.;Montgomery, Grant W.;Thompson, Philip J.
通讯作者：
Thompson, Philip J.
影响因子：
30.8
作者：
通讯作者：
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