Suicide attempts in major affective disorder patients with comorbid substance use disorders.
Suicide attempts in major affective disorder patients with comorbid substance use disorders.
复制标题
患有共病物质使用障碍的严重情感障碍患者的自杀企图。
DOI：
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复制
发表时间：
1999
影响因子：
5.3
通讯作者：
P. Mannu
中科院分区：
文献类型：
--
作者：
L. Tondo;R. Baldessarini;J. Hennen;G. Minnai;Piergiorgio Salis;L. Scamonatti;Mercedes Masia;C. Ghiani;P. Mannu
背景
通过文献综述和新的数据，对广泛接受的物质滥用和依赖与自杀风险增加相关的印象进行了评价。
方法
回顾了以前对这种关联的研究，并分析了意大利精神卫生系统附属撒丁岛4个精神科住院的504名心境障碍患者的自杀企图和物质使用的临床数据。
结果
文献支持酒精和药物使用与严重情感障碍的共病关系，以及某些物质（多药滥用、酒精、海洛因、可卡因，甚至烟草，但可能不是大麻或致幻剂）与自杀行为的关系。我们的新发现普遍支持这些双向关联。住院男性和女性的自杀风险相似，但与双相II型、双相I型（主要是混合型）、单相抑郁障碍以及物质滥用相关，药物类型影响不大。药物滥用在非混合型双相情感障碍、男性和30岁以下人群中更为常见。
结论
双相I型（主要为非混合型）患者药物滥用风险相对较高，自杀企图风险较低，这一趋势表明，主要为抑郁或烦躁（双相II型，非双相，双相I型，主要为混合型）的情绪障碍可能特别致命。男性和I型双相情感障碍患者药物滥用和自杀行为风险的差异进一步表明，药物滥用和情绪障碍可能导致自杀风险，至少部分独立或相加。
BACKGROUND
The widely accepted impression that substance abuse and dependence are associated with increased suicidal risk was evaluated by literature review and with new data.
METHOD
Previous research on this association was reviewed, and clinical data on suicide attempts and substance use in 504 mood disorder patients hospitalized in 4 psychiatric units in Sardinia affiliated with the Italian mental health system were analyzed.
RESULTS
The literature supports associations of alcohol and drug use comorbidity with major affective disorders, and of some substances (polyabuse, alcohol, heroin, cocaine, and even tobacco, but perhaps not marijuana or hallucinogens) with suicidal behavior. Our new findings generally supported these 2-way associations. Suicidal risks were similar in hospitalized men and women but were associated with bipolar II, bipolar I (mainly mixed), and unipolar depressive disorders as well as substance abuse, with little effect of type of agent. Substance abuse was more common in nonmixed bipolar disorders, men, and age below 30.
CONCLUSION
The tendency for bipolar I, mainly nonmixed patients, to have a relatively high risk of substance abuse and low risk of suicide attempts indicates that mainly depressive or dysphoric (bipolar II, nonbipolar, and bipolar I, mainly mixed) mood disorders may be especially lethal. Differences in risks of substance abuse and suicidal behavior in men and in bipolar I patients further suggest that substance abuse and mood disorders may contribute to suicidal risk with at least partial independence or additivity.
住院前 24 小时：与自杀企图相关的因素。
影响因子：
3.2
作者：
Chiles,JA;Strosahl,K;Cowden,L;Graham,R;Linehan,M
通讯作者：
Linehan,M
一年内自杀的纽约市居民吸食可卡因的比例。
DOI：
10.1176/ajp.149.3.371
发表时间：
1992
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Marzuk,PM;Tardiff,K;Leon,AC;Stajic,M;Morgan,EB;Mann,JJ
通讯作者：
Mann,JJ
影响因子：
3
作者：
HARLOW, LL;NEWCOMB, MD;BENTLER, PM
通讯作者：
BENTLER, PM