Genomic insights into chromatin reprogramming to totipotency in embryos.
Genomic insights into chromatin reprogramming to totipotency in embryos.
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DOI：
10.1083/jcb.201807044
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发表时间：
2019-01-07
期刊：
影响因子：
--
通讯作者：
Tachibana K
中科院分区：
文献类型：
--
作者：
Ladstätter S;Tachibana K
Ladstätter和Tachibana讨论了在早期胚胎中重新编程为全能性期间发生的DNA甲基化，染色质可及性和拓扑结构的变化。早期胚胎是获得全能性的天然原型，全能性是细胞产生整个有机体的潜力。全能胚胎的产生涉及染色质重组和改变DNA和组蛋白修饰的表观遗传重编程。了解胚胎染色质结构以及这与表观基因组和转录组的关系将为细胞命运决策提供宝贵的见解。最近出现的低输入基因组检测允许在稀少的哺乳动物胚胎中探索调控网络。因此，发育生物学领域正在从显微镜向全基因组染色质描述过渡。最终，原型成为研究发育、表观遗传重编程和细胞可塑性基本原理的独特模型。在这篇综述中，我们讨论了染色质重编程在早期小鼠胚胎，专注于DNA甲基化，染色质可及性，和高阶染色质结构。
Ladstätter and Tachibana discuss changes in DNA methylation, chromatin accessibility, and topological architecture occurring during the reprogramming to totipotency in the early embryo. The early embryo is the natural prototype for the acquisition of totipotency, which is the potential of a cell to produce a whole organism. Generation of a totipotent embryo involves chromatin reorganization and epigenetic reprogramming that alter DNA and histone modifications. Understanding embryonic chromatin architecture and how this is related to the epigenome and transcriptome will provide invaluable insights into cell fate decisions. Recently emerging low-input genomic assays allow the exploration of regulatory networks in the sparsely available mammalian embryo. Thus, the field of developmental biology is transitioning from microscopy to genome-wide chromatin descriptions. Ultimately, the prototype becomes a unique model for studying fundamental principles of development, epigenetic reprogramming, and cellular plasticity. In this review, we discuss chromatin reprogramming in the early mouse embryo, focusing on DNA methylation, chromatin accessibility, and higher-order chromatin structure.
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单细胞染色质可及性揭示了调节变化的原理。
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