Review article: vascular effects of PPARs in the context of NASH.
Review article: vascular effects of PPARs in the context of NASH.
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综述文章：NASH背景下PPAR的血管效应。
DOI：
10.1111/apt.17046
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发表时间：
2022-07
影响因子：
7.6
通讯作者：
Gracia-Sancho, Jordi
中科院分区：
文献类型：
--
作者：
Guixe-Muntet, Sergi;Biquard, Louise;Szabo, Gyongyi;Dufour, Jean-Francois;Tacke, Frank;Francque, Sven;Rautou, Pierre-Emmanuel;Gracia-Sancho, Jordi
Peroxisome proliferator‐activated receptors (PPARs) are ligand‐activated transcription factors known to regulate glucose and fatty acid metabolism, inflammation, endothelial function and fibrosis. PPAR isoforms have been extensively studied in metabolic diseases, including type 2 diabetes and cardiovascular diseases. Recent data extend the key role of PPARs to liver diseases coursing with vascular dysfunction, including nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). This review summarises and discusses the pathobiological role of PPARs in cardiovascular diseases with a special focus on their impact and therapeutic potential in NAFLD and NASH. PPARs may be attractive for the treatment of NASH due to their liver‐specific effects but also because of their efficacy in improving cardiovascular outcomes, which may later impact liver disease. Assessment of cardiovascular disease in the context of NASH trials is, therefore, of the utmost importance, both from a safety and efficacy perspective. PPARs are nuclear receptors that are involved in many vascular and metabolical processes, which may be common in the development and progression of NASH. In this article, we review the possible roles that PPARs may have on NASH in order to propose new therapeutic targets for this disease.
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影响因子：
16.2
作者：
Cariou B;Hanf R;Lambert-Porcheron S;Zaïr Y;Sauvinet V;Noël B;Flet L;Vidal H;Staels B;Laville M
通讯作者：
Laville M
DOI：
10.1161/atvbaha.112.300962
发表时间：
2013-04-01
影响因子：
8.7
作者：
Auclair, Martine;Vigouroux, Corinne;Caron-Debarle, Martine
通讯作者：
Caron-Debarle, Martine
影响因子：
4.2
作者：
Abdelmegeed, Mohamed A.;Yoo, Seong-Ho;Song, Byoung-Joon
通讯作者：
Song, Byoung-Joon
影响因子：
3.7
作者：
Dahlhoff C;Desmarchelier C;Sailer M;Fürst RW;Haag A;Ulbrich SE;Hummel B;Obeid R;Geisel J;Bader BL;Daniel H
通讯作者：
Daniel H
影响因子：
2.4
作者：
Dai Y;Zhu J;Meng D;Yu C;Li Y
通讯作者：
Li Y