Relationship between AGT rs2493132 polymorphism and the risk of coronary artery disease in patients with NAFLD in the Chinese Han population.
Relationship between AGT rs2493132 polymorphism and the risk of coronary artery disease in patients with NAFLD in the Chinese Han population.
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AGT rs2493132多态性与中国汉族人群NAFLD患者冠心病风险的关系
DOI：
10.1177/03000605211019263
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发表时间：
2021-07
期刊：
影响因子：
--
通讯作者：
Xuan S
中科院分区：
文献类型：
--
作者：
Dong M;Liu S;Wang M;Wang Y;Xin Y;Xuan S
探讨血管紧张素（AGT）rs2493132基因多态性与中国汉族人群非酒精性脂肪性肝病（NAFLD）和冠心病（CAD）的关系。聚合酶链反应检测AGT基因型。对青岛市立医院检验科的人体测量学和临床资料进行调查和统计分析。AGT rs2493132 CT + TT基因型是NAFLD患者和健康对照组NAFLD + CAD的重要危险因素。AGT rs2493132 T等位基因增加了健康对照中NAFLD + CAD的风险。在校正年龄、性别和体重指数后，AGT rs2493132 CT + TT基因型和T等位基因也显著增加NAFLD患者的CAD风险。此外，AGT rs2493132 T等位基因携带者与非携带者相比，总胆固醇（TC）和低密度脂蛋白（LDL）水平较高。AGT rs2493132 CT + TT基因型和T等位基因显著增加中国汉族人群NAFLD患者发生CAD的风险。AGT rs2493132 T等位基因与血清TC和LDL水平升高相关。
To investigate the relationship between angiotensin (AGT) rs2493132 gene polymorphism and the risk of developing non-alcoholic fatty liver disease (NAFLD) and coronary artery disease (CAD) in the Chinese Han population. Polymerase chain reaction was performed to determine AGT genotypes. Anthropometric and clinical data were investigated and statistically analyzed in the clinical laboratory department of Qingdao Municipal Hospital. The AGT rs2493132 CT + TT genotype was an important risk factor for CAD in patients with NAFLD and NAFLD + CAD in healthy controls. The AGT rs2493132 T allele increased the risk of NAFLD + CAD in healthy controls. The AGT rs2493132 CT + TT genotype and T allele also significantly increased the risk of CAD in patients with NAFLD after adjustments for age, sex, and body mass index. In addition, AGT rs2493132 T allele carriers showed higher total cholesterol (TC) and low-density lipoprotein (LDL) levels compared with non-carriers. The AGT rs2493132 CT + TT genotype and T allele significantly increased the risk of developing CAD in patients with NAFLD in the Chinese Han population. The AGT rs2493132 T allele was associated with increased serum TC and LDL levels.
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DOI：
10.1161/atvbaha.115.306740
发表时间：
2016-02
期刊：
Arteriosclerosis, thrombosis, and vascular biology
影响因子：
--
作者：
Lu H;Wu C;Howatt DA;Balakrishnan A;Moorleghen JJ;Chen X;Zhao M;Graham MJ;Mullick AE;Crooke RM;Feldman DL;Cassis LA;Vander Kooi CW;Daugherty A
通讯作者：
Daugherty A
影响因子：
5.1
作者：
Brouwers, Martijn C. G. J.;Simons, Nynke;Isaacs, Aaron
通讯作者：
Isaacs, Aaron
影响因子：
3.6
作者：
Liu, Hui-Hui;Cao, Ye-Xuan;Li, Jian-Jun
通讯作者：
Li, Jian-Jun
TRIB1 rs17321515基因多态性增加一般人群冠心病和中国汉族人群非酒精性脂肪肝患者的患病风险
影响因子：
4.5
作者：
Liu, Qun;Liu, Shou-Sheng;Xin, Yong-Ning
通讯作者：
Xin, Yong-Ning
影响因子：
3.7
作者：
Ji L;Cai X;Zhang L;Fei L;Wang L;Su J;Lazar L;Xu J;Zhang Y
通讯作者：
Zhang Y