Limited Awareness and Low Immediate Uptake of Pre-Exposure Prophylaxis among Men Who Have Sex with Men Using an Internet Social Networking Site.
Limited Awareness and Low Immediate Uptake of Pre-Exposure Prophylaxis among Men Who Have Sex with Men Using an Internet Social Networking Site.
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DOI：
10.1371/journal.pone.0033119
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Mayer KH
中科院分区：
文献类型：
--
作者：
Krakower DS;Mimiaga MJ;Rosenberger JG;Novak DS;Mitty JA;White JM;Mayer KH
2010年，iPrEx试验表明，口服抗逆转录病毒暴露前预防（PrEP）降低了高风险男男性行为者（MSM）感染艾滋病毒的风险。iPrEx对PrEP知识和高危MSM实际使用的影响尚不清楚。进行在线调查，以评估在iPrEx之前和之后的风险MSM中的PrEP意识，兴趣和经验，并确定与这些措施相关的人口统计学和行为因素。横截面，国家，基于互联网的调查管理，以美国为基础的成员最流行的美国男男性接触者社交网站2个月前（n = 398）和1个月后（n = 4 558）的iPrEx结果的出版物。 在这些样本之间进行了关于PrEP知识，兴趣和经验的比较。收集了人口统计学、性风险和暴露后预防（PEP）经验方面的数据。进行回归分析，以确定与PrEP意识、兴趣和iPrEx后经验相关的因素。大多数参与者是白色，受过教育，并表示高风险的性行为。在iPrEx前后，对PrEP的认识有限（13%对19%），而在提供PrEP描述后，兴趣水平仍然很高（76%对79%）。PrEP使用仍然不常见（0.7%对0.9%）。PrEP使用与PEP意识（OR 7.46; CI 1.52 - 36.6）和PEP经验（OR 34.2; CI 13.3 - 88.4）相关。对PrEP的兴趣与年龄较大（OR 1.01; CI 1.00 - 1.02）、前3个月内与≥ 1名男性伴侣无保护肛交（OR 1.40; CI 1.10 - 1.77）以及认为自己感染HIV的风险增加（OR 1.20; CI 1.13 - 1.27）相关。在从事在线网络的MSM中，在iPrEx数据发布后1个月，对PrEP的认识有限。利用率很低，虽然一些男男性接触者报告的高风险行为有兴趣使用PrEP。需要研究来了解风险男男性接触者使用PrEP的障碍。
In 2010, the iPrEx trial demonstrated that oral antiretroviral pre-exposure prophylaxis (PrEP) reduced the risk of HIV acquisition among high-risk men who have sex with men (MSM). The impact of iPrEx on PrEP knowledge and actual use among at-risk MSM is unknown. Online surveys were conducted to assess PrEP awareness, interest and experience among at-risk MSM before and after iPrEx, and to determine demographic and behavioral factors associated with these measures. Cross-sectional, national, internet-based surveys were administered to U.S. based members of the most popular American MSM social networking site 2 months before (n = 398) and 1 month after (n = 4 558) publication of iPrEx results. Comparisons were made between these samples with regards to PrEP knowledge, interest, and experience. Data were collected on demographics, sexual risk, and experience with post-exposure prophylaxis (PEP). Regression analyses were performed to identify factors associated with PrEP awareness, interest, and experience post-iPrEx. Most participants were white, educated, and indicated high-risk sexual behaviors. Awareness of PrEP was limited pre- and post-iPrEx (13% vs. 19%), whereas interest levels after being provided with a description of PrEP remained high (76% vs. 79%). PrEP use remained uncommon (0.7% vs. 0.9%). PrEP use was associated with PEP awareness (OR 7.46; CI 1.52–36.6) and PEP experience (OR 34.2; CI 13.3–88.4). PrEP interest was associated with older age (OR 1.01; CI 1.00–1.02), unprotected anal intercourse with ≥1 male partner in the prior 3 months (OR 1.40; CI 1.10–1.77), and perceiving oneself at increased risk for HIV acquisition (OR 1.20; CI 1.13–1.27). Among MSM engaged in online networking, awareness of PrEP was limited 1 month after the iPrEx data were released. Utilization was low, although some MSM who reported high-risk behaviors were interested in using PrEP. Studies are needed to understand barriers to PrEP utilization by at-risk MSM.
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DOI：
10.1097/qai.0b013e3181e19a54
发表时间：
2010-08
期刊：
Journal of acquired immune deficiency syndromes (1999)
影响因子：
--
作者：
Golub SA;Kowalczyk W;Weinberger CL;Parsons JT
通讯作者：
Parsons JT
DOI：
10.1007/s11524-005-9008-3
发表时间：
2006-01-01
影响因子：
6.6
作者：
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Remien, RH
影响因子：
3.8
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Sherr, L
影响因子：
7.4
作者：
Khosropour CM;Sullivan PS
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Sullivan PS
影响因子：
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